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- W2400432840 abstract "Considerable evidence indicates that select chemical compounds, particularly antibiotics, mediate their effect by acting on membrane systems. Secretion or transport of pancreatic digestive enzymes represent, at least in part, membrane-associated functions. For these reasons, experiments were designed to determine effects of antibiotics on amylase secretion in vitro. Pancreatic slices were incubated aerobically in tissue culture media containing different concentrations of drugs. Amylase secretion into media and tissue amylase content were measured. Increases in secretion of amylase were found when tissue from fed or fed animals given bethanechol chloride was compared with fasted control animals. Minimal secretion and decreases in tissue were observed under anaerobic incubation. Atropine did not alter secretion but reduced tissue amylase content. Cyanide sharply diminished amylase secretion. Tetracycline, valinomycin, and amphotericin Β decreased secretion without altering tissue amylase content. Lidocaine increased secretion without altering tissue amylase content. Streptomycin increased secretion and decreased tissue content. Puromycin and actinomycin D did not alter secretion but significantly reduced amylase content. These studies show that select drugs, known to alter membrane function, also alter secretion." @default.
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- W2400432840 date "1972-09-01" @default.
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- W2400432840 title "Effect of Drugs on Pancreatic Amylase Secretion in Vitro" @default.
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- W2400432840 doi "https://doi.org/10.1016/s0016-5085(19)33294-9" @default.
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