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• W2400493339 endingPage "774" @default.
• W2400493339 startingPage "761" @default.
• W2400493339 abstract "Aims: Selenocysteine lyase (Scly) mediates selenocysteine decomposition. It was previously demonstrated that, upon adequate caloric intake (12% kcal fat) and selenium deficiency, disruption of Scly in mice leads to development of metabolic syndrome. In this study, we investigate the effect of a high-fat (45% kcal) selenium-adequate diet in Scly knockout (KO) mice on development of metabolic syndrome. Involvement of selenoproteins in energy metabolism after Scly disruption was also examined in vitro in the murine hepatoma cell line, Hepa1-6, following palmitate treatment. Results: Scly KO mice were more susceptible to diet-induced obesity than their wild-type counterparts after feeding a high-fat selenium-adequate diet. Scly KO mice had aggravated hyperinsulinemia, hypercholesterolemia, glucose, and insulin intolerance, but unchanged inflammatory cytokines and expression of most selenoproteins, except increased serum selenoprotein P (Sepp1). Scly KO mice also exhibited enhanced hepatic levels of pyruvate and enzymes involved in the regulation of pyruvate cycling, such as pyruvate carboxylase (Pcx) and pyruvate dehydrogenase (Pdh). However, in vitro silencing of Scly in Hepa1-6 cells led to diminished Sepp1 expression, and concomitant palmitate treatment decreased Pdh expression. Innovation: The role of selenium in lipid metabolism is recognized, but specific selenium-dependent mechanisms leading to obesity are unclear. This study uncovers that Scly has a remarkable effect on obesity and metabolic syndrome development triggered by high-fat exposure, independent of the expression of most selenoproteins. Conclusion: Diet-induced obesity in Scly KO mice is aggravated, with effects on pyruvate levels and consequent activation of energy metabolism independent of selenoprotein levels. Antioxid. Redox Signal. 23, 761–774." @default.
• W2400493339 created "2016-06-24" @default.
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• W2400493339 creator A5047512410 @default.
• W2400493339 creator A5053452968 @default.
• W2400493339 date "2015-10-01" @default.
• W2400493339 modified "2023-10-16" @default.
• W2400493339 title "Diet-Induced Obesity in the Selenocysteine Lyase Knockout Mouse" @default.
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• W2400493339 doi "https://doi.org/10.1089/ars.2015.6277" @default.
• W2400493339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589310" @default.
• W2400493339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26192035" @default.
• W2400493339 hasPublicationYear "2015" @default.
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