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- W2400507908 abstract "Thrombus formation presents a serious hindrance in the development of functional artificial blood vessels, especially those with a small diameter. Endothelialization can prevent thrombus formation; however, the adhesion of endothelial cells to existing polymer materials is generally weak. Therefore, polymers that have both anti-thrombotic and endothelialization properties do not currently exist. We previously reported that platelets do not adhere to poly(2-methoxyethyl acrylate) (PMEA) or poly(tetrahydrofurfuryl acrylate)(PTHFA). Here, we investigated whether endothelial cells and smooth muscle cells, both of which are blood vessel components, could adhere to these synthetic polymers. Polyethylene terephthalate films were coated with PMEA and PTHFA using a spin-coater. Human umbilical vein endothelial cells or aorta smooth muscle cells were seeded on the polymer surfaces, after which we analyzed the number of adherent cells, their morphologies and vinculin expression. We found that both endothelial and smooth muscle cells adhered to PMEA and PTHFA, while platelets did not. We propose that, by using PMEA and PTHFA with no modifications, it should be possible to develop artificial blood vessels with both anti-thrombotic and endothelialization properties. In addition, we discuss the mechanism of selective cell adhesion in PMEA and PTHFA." @default.
- W2400507908 created "2016-06-24" @default.
- W2400507908 creator A5011623800 @default.
- W2400507908 creator A5060477607 @default.
- W2400507908 creator A5081883958 @default.
- W2400507908 date "2016-09-01" @default.
- W2400507908 modified "2023-10-10" @default.
- W2400507908 title "Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells." @default.
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- W2400507908 doi "https://doi.org/10.1016/j.colsurfb.2016.05.057" @default.
- W2400507908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27285730" @default.
- W2400507908 hasPublicationYear "2016" @default.
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