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- W2400520418 endingPage "10" @default.
- W2400520418 startingPage "1" @default.
- W2400520418 abstract "Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sensitive and specific markers in addition to albuminuria are needed to predict the early onset and progression of DN. Tubular injury, as shown by the detection of tubular injury markers in the urine, is a critical component of the early course of DN. These urinary tubular markers may increase in diabetic patients, even before diagnosis of microalbuminuria representing early markers of normoalbuminuric DN. In this review we summarized some new and important urinary markers of tubular injury, such as neutrophil gelatinase associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty acid binding protein (L-FABP), N-acetyl-beta-glucosaminidase (NAG), alpha-1 microglobulin (A1M), beta 2-microglobulin (B2-M), and retinol binding protein (RBP) associated with early DN." @default.
- W2400520418 created "2016-06-24" @default.
- W2400520418 creator A5047548508 @default.
- W2400520418 creator A5087085895 @default.
- W2400520418 date "2016-01-01" @default.
- W2400520418 modified "2023-09-30" @default.
- W2400520418 title "Urinary Markers of Tubular Injury in Early Diabetic Nephropathy" @default.
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