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- W2400533248 abstract "Drugs that alter the function of two of the major brain monoamine neurotransmitter systems (the noradrenergic [NE] and serotonergic [5HT]), have been shown to alter levels of “fear and anxiety” in laboratory animals, healthy humans, and patients. The relative clinical efficacy in the treatment of anxiety disorders with many of these drugs also emphasizes the importance of these two systems in anxiety. Stimulation of the 5-HT system does not produce marked abnormalities in patients with anxiety, but stimulation of the NE system does produce abnormal changes in measures of anxiety, somatic symptoms, blood pressure, and a plasma NE metabolite and cortisol levels in patients with panic disorder but not in patients with generalized anxiety disorder, obsessive-compulsive disorder, depression, or schizophrenia. This indicates that some patients with panic disorder have an abnormality in the regulation of the NE system, which could explain many of the clinical features of this syndrome." @default.
- W2400533248 created "2016-06-24" @default.
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- W2400533248 creator A5039312313 @default.
- W2400533248 date "1988-06-01" @default.
- W2400533248 modified "2023-10-05" @default.
- W2400533248 title "Monoamine Receptor Systems and Anxiety Disorders" @default.
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- W2400533248 doi "https://doi.org/10.1016/s0193-953x(18)30499-4" @default.
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