Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400547822> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2400547822 endingPage "61" @default.
- W2400547822 startingPage "353" @default.
- W2400547822 abstract "A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol specific phospholipase C (PtdInsPLC) has been developed. Three naturally occurring peptide inhibitors of PtdInsPLC have been identified, myroridin K, streptothricin B and edeine, with IC50 values of 8.3, 6.7 and 16.1 microM, respectively. All three peptides inhibited colony formation of HT-29 human colon adenocarcinoma cells, with IC50 values of 7.2, 3.9 and 13.0 microM, respectively. The compounds also inhibited the growth of other human cancer cells in culture. One of the peptides, myroridin K, has previously been reported to have in vivo antitumour activity. It is possible that inhibition of PtdInsPLC is responsible for the cell growth inhibition and antitumour properties of the peptide compounds." @default.
- W2400547822 created "2016-06-24" @default.
- W2400547822 creator A5000139221 @default.
- W2400547822 creator A5003235993 @default.
- W2400547822 creator A5011101496 @default.
- W2400547822 creator A5036639054 @default.
- W2400547822 creator A5042892814 @default.
- W2400547822 creator A5081107635 @default.
- W2400547822 date "1994-08-01" @default.
- W2400547822 modified "2023-09-23" @default.
- W2400547822 title "A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity." @default.
- W2400547822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7916901" @default.
- W2400547822 hasPublicationYear "1994" @default.
- W2400547822 type Work @default.
- W2400547822 sameAs 2400547822 @default.
- W2400547822 citedByCount "6" @default.
- W2400547822 countsByYear W24005478222018 @default.
- W2400547822 countsByYear W24005478222021 @default.
- W2400547822 crossrefType "journal-article" @default.
- W2400547822 hasAuthorship W2400547822A5000139221 @default.
- W2400547822 hasAuthorship W2400547822A5003235993 @default.
- W2400547822 hasAuthorship W2400547822A5011101496 @default.
- W2400547822 hasAuthorship W2400547822A5036639054 @default.
- W2400547822 hasAuthorship W2400547822A5042892814 @default.
- W2400547822 hasAuthorship W2400547822A5081107635 @default.
- W2400547822 hasConcept C116073593 @default.
- W2400547822 hasConcept C121608353 @default.
- W2400547822 hasConcept C12927208 @default.
- W2400547822 hasConcept C150903083 @default.
- W2400547822 hasConcept C181199279 @default.
- W2400547822 hasConcept C185592680 @default.
- W2400547822 hasConcept C202751555 @default.
- W2400547822 hasConcept C207001950 @default.
- W2400547822 hasConcept C2776980637 @default.
- W2400547822 hasConcept C2777752497 @default.
- W2400547822 hasConcept C2778597717 @default.
- W2400547822 hasConcept C2779281246 @default.
- W2400547822 hasConcept C2779707156 @default.
- W2400547822 hasConcept C2780610907 @default.
- W2400547822 hasConcept C54355233 @default.
- W2400547822 hasConcept C55493867 @default.
- W2400547822 hasConcept C6182249 @default.
- W2400547822 hasConcept C62112901 @default.
- W2400547822 hasConcept C62478195 @default.
- W2400547822 hasConcept C81885089 @default.
- W2400547822 hasConcept C86803240 @default.
- W2400547822 hasConcept C96232424 @default.
- W2400547822 hasConceptScore W2400547822C116073593 @default.
- W2400547822 hasConceptScore W2400547822C121608353 @default.
- W2400547822 hasConceptScore W2400547822C12927208 @default.
- W2400547822 hasConceptScore W2400547822C150903083 @default.
- W2400547822 hasConceptScore W2400547822C181199279 @default.
- W2400547822 hasConceptScore W2400547822C185592680 @default.
- W2400547822 hasConceptScore W2400547822C202751555 @default.
- W2400547822 hasConceptScore W2400547822C207001950 @default.
- W2400547822 hasConceptScore W2400547822C2776980637 @default.
- W2400547822 hasConceptScore W2400547822C2777752497 @default.
- W2400547822 hasConceptScore W2400547822C2778597717 @default.
- W2400547822 hasConceptScore W2400547822C2779281246 @default.
- W2400547822 hasConceptScore W2400547822C2779707156 @default.
- W2400547822 hasConceptScore W2400547822C2780610907 @default.
- W2400547822 hasConceptScore W2400547822C54355233 @default.
- W2400547822 hasConceptScore W2400547822C55493867 @default.
- W2400547822 hasConceptScore W2400547822C6182249 @default.
- W2400547822 hasConceptScore W2400547822C62112901 @default.
- W2400547822 hasConceptScore W2400547822C62478195 @default.
- W2400547822 hasConceptScore W2400547822C81885089 @default.
- W2400547822 hasConceptScore W2400547822C86803240 @default.
- W2400547822 hasConceptScore W2400547822C96232424 @default.
- W2400547822 hasIssue "4" @default.
- W2400547822 hasLocation W24005478221 @default.
- W2400547822 hasOpenAccess W2400547822 @default.
- W2400547822 hasPrimaryLocation W24005478221 @default.
- W2400547822 hasRelatedWork W1763215782 @default.
- W2400547822 hasRelatedWork W1977769302 @default.
- W2400547822 hasRelatedWork W2011603959 @default.
- W2400547822 hasRelatedWork W2050603236 @default.
- W2400547822 hasRelatedWork W2052410183 @default.
- W2400547822 hasRelatedWork W2055617588 @default.
- W2400547822 hasRelatedWork W2058894303 @default.
- W2400547822 hasRelatedWork W2088772280 @default.
- W2400547822 hasRelatedWork W2393376591 @default.
- W2400547822 hasRelatedWork W2400547822 @default.
- W2400547822 hasVolume "9" @default.
- W2400547822 isParatext "false" @default.
- W2400547822 isRetracted "false" @default.
- W2400547822 magId "2400547822" @default.
- W2400547822 workType "article" @default.