Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400569110> ?p ?o ?g. }
- W2400569110 endingPage "123" @default.
- W2400569110 startingPage "83" @default.
- W2400569110 abstract "Listeria monocytogenes is responsible for one of the most life-threatening food-borne infections and the leading cause of food-poisoning associated deaths in the UK. Infection may be of the unborn/newly born infant where disease may manifest as listeric abortion, stillbirth or late-onset neonatal listeriosis, while in adults, infection usually affects the central nervous system causing meningitis. Crucial to the survival of L. monocytogenes, both inside and outside the host, is its ability to acquire metals which act as cofactors for a broad range of its cellular proteins. However, L. monocytogenes must also protect itself against the innate toxicity of metals. The importance of metals in host-pathogen interactions is illustrated by the restriction of metals (including zinc and iron) in vertebrates in response to infection and the use of high levels of metals (copper and zinc) as part of the antimicrobial defences within host phagocytes. As such, L. monocytogenes is equipped with various mechanisms to tightly control its cellular metal pools and avoid metal poisoning. These include multiple DNA-binding metal-responsive transcription factors, metal-acquisition, metal-detoxification and metal-storage systems, some of which represent key L. monocytogenes virulence determinants. This review discusses current knowledge of the role of metals in L. monocytogenes infections, with a focus on the mechanisms that contribute to zinc and copper homeostasis in this organism. The requirement to precisely control cellular metal levels may impose a vulnerability to L. monocytogenes which can be exploited in antimicrobials and therapeutics." @default.
- W2400569110 created "2016-06-24" @default.
- W2400569110 creator A5006998497 @default.
- W2400569110 creator A5029098764 @default.
- W2400569110 creator A5052719640 @default.
- W2400569110 date "2014-01-01" @default.
- W2400569110 modified "2023-10-18" @default.
- W2400569110 title "Metal Ion Homeostasis in Listeria monocytogenes and Importance in Host–Pathogen Interactions" @default.
- W2400569110 cites W1504554302 @default.
- W2400569110 cites W1504850650 @default.
- W2400569110 cites W1509086826 @default.
- W2400569110 cites W1541274285 @default.
- W2400569110 cites W1548370164 @default.
- W2400569110 cites W1571768010 @default.
- W2400569110 cites W1572855322 @default.
- W2400569110 cites W1574621162 @default.
- W2400569110 cites W1582036401 @default.
- W2400569110 cites W1596689072 @default.
- W2400569110 cites W1606449940 @default.
- W2400569110 cites W1775175420 @default.
- W2400569110 cites W1878762030 @default.
- W2400569110 cites W1894302566 @default.
- W2400569110 cites W1900581805 @default.
- W2400569110 cites W1925104015 @default.
- W2400569110 cites W1952125891 @default.
- W2400569110 cites W1964339096 @default.
- W2400569110 cites W1964562548 @default.
- W2400569110 cites W1964818207 @default.
- W2400569110 cites W1968332714 @default.
- W2400569110 cites W1968650556 @default.
- W2400569110 cites W1970567891 @default.
- W2400569110 cites W1970762630 @default.
- W2400569110 cites W1972020470 @default.
- W2400569110 cites W1972753930 @default.
- W2400569110 cites W1973239186 @default.
- W2400569110 cites W1974248955 @default.
- W2400569110 cites W1975183148 @default.
- W2400569110 cites W1975187969 @default.
- W2400569110 cites W1978381847 @default.
- W2400569110 cites W1979488926 @default.
- W2400569110 cites W1982245868 @default.
- W2400569110 cites W1983281945 @default.
- W2400569110 cites W1987287925 @default.
- W2400569110 cites W1987816685 @default.
- W2400569110 cites W1990761952 @default.
- W2400569110 cites W1990807321 @default.
- W2400569110 cites W1991303877 @default.
- W2400569110 cites W1991499425 @default.
- W2400569110 cites W1994677299 @default.
- W2400569110 cites W1995732138 @default.
- W2400569110 cites W1996314851 @default.
- W2400569110 cites W1996641418 @default.
- W2400569110 cites W2004398009 @default.
- W2400569110 cites W2004905031 @default.
- W2400569110 cites W2005060189 @default.
- W2400569110 cites W2009869786 @default.
- W2400569110 cites W2010168640 @default.
- W2400569110 cites W2011005794 @default.
- W2400569110 cites W2011138772 @default.
- W2400569110 cites W2011388752 @default.
- W2400569110 cites W2011515525 @default.
- W2400569110 cites W2013034108 @default.
- W2400569110 cites W2016802844 @default.
- W2400569110 cites W2017980572 @default.
- W2400569110 cites W2019132845 @default.
- W2400569110 cites W2019725457 @default.
- W2400569110 cites W2020455774 @default.
- W2400569110 cites W2020557929 @default.
- W2400569110 cites W2021407725 @default.
- W2400569110 cites W2025081536 @default.
- W2400569110 cites W2026119795 @default.
- W2400569110 cites W2028585334 @default.
- W2400569110 cites W2029105004 @default.
- W2400569110 cites W2029291491 @default.
- W2400569110 cites W2031739850 @default.
- W2400569110 cites W2031873778 @default.
- W2400569110 cites W2033139184 @default.
- W2400569110 cites W2034252508 @default.
- W2400569110 cites W2034435585 @default.
- W2400569110 cites W2035594105 @default.
- W2400569110 cites W2037434831 @default.
- W2400569110 cites W2037658357 @default.
- W2400569110 cites W2039176236 @default.
- W2400569110 cites W2039859631 @default.
- W2400569110 cites W2043422770 @default.
- W2400569110 cites W2043986265 @default.
- W2400569110 cites W2044678473 @default.
- W2400569110 cites W2046567673 @default.
- W2400569110 cites W2048053078 @default.
- W2400569110 cites W2048443522 @default.
- W2400569110 cites W2049085442 @default.
- W2400569110 cites W2049550628 @default.
- W2400569110 cites W2051328663 @default.
- W2400569110 cites W2051659971 @default.
- W2400569110 cites W2052097550 @default.
- W2400569110 cites W2055378505 @default.
- W2400569110 cites W2057549168 @default.
- W2400569110 cites W2058274420 @default.