Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400577369> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2400577369 endingPage "202" @default.
- W2400577369 startingPage "195" @default.
- W2400577369 abstract "Increases in basal and catecholamine-responsive adenylate cyclase activity have been observed in livers of rats treated with the carcinogen 39-methyl-4-dimethylaminoazobenzene (39-MeDAB). These increases are accompanied by a decrease in glucagon responsiveness of the enzyme. Binding of 39-MeDAB metabolites reaches a peak at 3 weeks, considerably earlier than the peak increases in adenylate cyclase activity at 6 weeks. By the time tumors are detected in the tissue (10-20 weeks), adenylate cyclase activity and response to catecholamine stimulation are back to or below normal. The greatly increased stimulation of adenylate cyclase activity by catecholamines is a beta receptor effect; however, inhibition of the enzyme by catecholamines is also seen when there is elevated basal activity and may be an alpha adrenergic effect. That glucagon and catecholamine effects are additive at certain concentrations of catecholamine, but only partially so at others, indicates that the two receptor-cyclase systems are not entirely separate. The preneoplastic rat liver would appear to be a suitable tissue to study hormone-receptor interactions at both molecular and physiological levels. It is the first broken cell preparation in which inhibitory effects of catecholamines on adenylate cyclase activity have been observed. The relationship between the observed changes and the induction of cancer is not yet clear." @default.
- W2400577369 created "2016-06-24" @default.
- W2400577369 creator A5040956337 @default.
- W2400577369 creator A5069853428 @default.
- W2400577369 date "1976-03-01" @default.
- W2400577369 modified "2023-09-23" @default.
- W2400577369 title "Changes in catecholamine- and glucagon-responsive adenylate cyclase activity in preneoplastic rat liver." @default.
- W2400577369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1264065" @default.
- W2400577369 hasPublicationYear "1976" @default.
- W2400577369 type Work @default.
- W2400577369 sameAs 2400577369 @default.
- W2400577369 citedByCount "7" @default.
- W2400577369 countsByYear W24005773692016 @default.
- W2400577369 crossrefType "journal-article" @default.
- W2400577369 hasAuthorship W2400577369A5040956337 @default.
- W2400577369 hasAuthorship W2400577369A5069853428 @default.
- W2400577369 hasConcept C126322002 @default.
- W2400577369 hasConcept C134018914 @default.
- W2400577369 hasConcept C170493617 @default.
- W2400577369 hasConcept C180526460 @default.
- W2400577369 hasConcept C185592680 @default.
- W2400577369 hasConcept C24998067 @default.
- W2400577369 hasConcept C2775859304 @default.
- W2400577369 hasConcept C2775894120 @default.
- W2400577369 hasConcept C2778024521 @default.
- W2400577369 hasConcept C2778563252 @default.
- W2400577369 hasConcept C2779306644 @default.
- W2400577369 hasConcept C2780069284 @default.
- W2400577369 hasConcept C71315377 @default.
- W2400577369 hasConcept C71924100 @default.
- W2400577369 hasConcept C86803240 @default.
- W2400577369 hasConceptScore W2400577369C126322002 @default.
- W2400577369 hasConceptScore W2400577369C134018914 @default.
- W2400577369 hasConceptScore W2400577369C170493617 @default.
- W2400577369 hasConceptScore W2400577369C180526460 @default.
- W2400577369 hasConceptScore W2400577369C185592680 @default.
- W2400577369 hasConceptScore W2400577369C24998067 @default.
- W2400577369 hasConceptScore W2400577369C2775859304 @default.
- W2400577369 hasConceptScore W2400577369C2775894120 @default.
- W2400577369 hasConceptScore W2400577369C2778024521 @default.
- W2400577369 hasConceptScore W2400577369C2778563252 @default.
- W2400577369 hasConceptScore W2400577369C2779306644 @default.
- W2400577369 hasConceptScore W2400577369C2780069284 @default.
- W2400577369 hasConceptScore W2400577369C71315377 @default.
- W2400577369 hasConceptScore W2400577369C71924100 @default.
- W2400577369 hasConceptScore W2400577369C86803240 @default.
- W2400577369 hasIssue "2" @default.
- W2400577369 hasLocation W24005773691 @default.
- W2400577369 hasOpenAccess W2400577369 @default.
- W2400577369 hasPrimaryLocation W24005773691 @default.
- W2400577369 hasRelatedWork W2012402433 @default.
- W2400577369 hasRelatedWork W2019107681 @default.
- W2400577369 hasRelatedWork W2027893724 @default.
- W2400577369 hasRelatedWork W2039781946 @default.
- W2400577369 hasRelatedWork W2042164169 @default.
- W2400577369 hasRelatedWork W2046261096 @default.
- W2400577369 hasRelatedWork W2073660731 @default.
- W2400577369 hasRelatedWork W2083737357 @default.
- W2400577369 hasRelatedWork W2295544200 @default.
- W2400577369 hasRelatedWork W4243558404 @default.
- W2400577369 hasVolume "12" @default.
- W2400577369 isParatext "false" @default.
- W2400577369 isRetracted "false" @default.
- W2400577369 magId "2400577369" @default.
- W2400577369 workType "article" @default.