FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400612805> ?p ?o ?g. }

• W2400612805 endingPage "696" @default.
• W2400612805 startingPage "689" @default.
• W2400612805 abstract "The modification of Wnt and Notch signaling pathways by hypoxia, and its association with osteoblast proliferation and apoptosis remain to be fully elucidated. To investigate Wnt-Notch crosstalk, and its role in hypoxia-induced osteoblast proliferation and apoptosis regulation, the present study investigated the effects of cobalt‑mimicked hypoxia on the mouse pre-osteoblast-like cell line, MC3T3‑E1, when the Notch signals were repressed using a γ‑secretase inhibitor DAPT. The data showed that the cobalt‑mimicked hypoxia suppressed cell proliferation under normal conditions, but increased cell proliferation under conditions of Notch repression, in a concentration‑dependent manner. The results of western blot and reverse transcription‑quantitative polymerase chain reaction analyses showed that the cobalt treatment increased the levels of activated β‑catenin protein and the expression levels of the target genes, axis inhibition protein 2 and myelocytomatosis oncogene, under DAPT‑induced Notch repression. However, no significant changes were found in the expression levels of the Notch intracellular domain protein or the Notch target gene, hes1. In a β‑catenin gene‑knockdown experiment, the proliferation of the MC3T3‑E1 cells under hypoxia were decreased by DAPT treatment, and knockdown of the expression of hypoxia‑inducible factor‑1α (HIF‑1α) suppressed the cobalt‑induced increase in Wnt target gene levels. No significant difference in cell proliferation rate was found following DAPT treatment when the expression of HIF‑1α was knocked down. The results of the present study showed the opposing effects of Wnt and Notch signaling under cobalt‑mimicked hypoxia, which were partially regulated by HIF‑1α, The results also showed that osteoblast proliferation was dependent on Wnt-Notch signal crosstalk." @default.
• W2400612805 created "2016-06-24" @default.
• W2400612805 creator A5016976734 @default.
• W2400612805 creator A5023213159 @default.
• W2400612805 creator A5029530550 @default.
• W2400612805 creator A5063000014 @default.
• W2400612805 creator A5081675173 @default.
• W2400612805 creator A5091366811 @default.
• W2400612805 date "2016-05-23" @default.
• W2400612805 modified "2023-09-29" @default.
• W2400612805 title "Notch signaling represses hypoxia-inducible factor-1α-induced activation of Wnt/β-catenin signaling in osteoblasts under cobalt-mimicked hypoxia" @default.
• W2400612805 cites W1796950446 @default.
• W2400612805 cites W1978047251 @default.
• W2400612805 cites W1981055008 @default.
• W2400612805 cites W2007904774 @default.
• W2400612805 cites W2009441433 @default.
• W2400612805 cites W2024988321 @default.
• W2400612805 cites W2035521614 @default.
• W2400612805 cites W2045936444 @default.
• W2400612805 cites W2052152283 @default.
• W2400612805 cites W2058992881 @default.
• W2400612805 cites W2060959662 @default.
• W2400612805 cites W2064140455 @default.
• W2400612805 cites W2068734526 @default.
• W2400612805 cites W2084902893 @default.
• W2400612805 cites W2089254126 @default.
• W2400612805 cites W2091891304 @default.
• W2400612805 cites W2092029433 @default.
• W2400612805 cites W2104551938 @default.
• W2400612805 cites W2147162859 @default.
• W2400612805 cites W2155012110 @default.
• W2400612805 cites W2169038550 @default.
• W2400612805 cites W2180975946 @default.
• W2400612805 cites W2239533402 @default.
• W2400612805 cites W2513292995 @default.
• W2400612805 doi "https://doi.org/10.3892/mmr.2016.5324" @default.
• W2400612805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4918618" @default.
• W2400612805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27220406" @default.
• W2400612805 hasPublicationYear "2016" @default.
• W2400612805 type Work @default.
• W2400612805 sameAs 2400612805 @default.
• W2400612805 citedByCount "14" @default.
• W2400612805 countsByYear W24006128052017 @default.
• W2400612805 countsByYear W24006128052018 @default.
• W2400612805 countsByYear W24006128052019 @default.
• W2400612805 countsByYear W24006128052020 @default.
• W2400612805 countsByYear W24006128052022 @default.
• W2400612805 countsByYear W24006128052023 @default.
• W2400612805 crossrefType "journal-article" @default.
• W2400612805 hasAuthorship W2400612805A5016976734 @default.
• W2400612805 hasAuthorship W2400612805A5023213159 @default.
• W2400612805 hasAuthorship W2400612805A5029530550 @default.
• W2400612805 hasAuthorship W2400612805A5063000014 @default.
• W2400612805 hasAuthorship W2400612805A5081675173 @default.
• W2400612805 hasAuthorship W2400612805A5091366811 @default.
• W2400612805 hasBestOaLocation W24006128051 @default.
• W2400612805 hasConcept C104317684 @default.
• W2400612805 hasConcept C137620995 @default.
• W2400612805 hasConcept C153911025 @default.
• W2400612805 hasConcept C160450060 @default.
• W2400612805 hasConcept C161879069 @default.
• W2400612805 hasConcept C173396325 @default.
• W2400612805 hasConcept C185592680 @default.
• W2400612805 hasConcept C190283241 @default.
• W2400612805 hasConcept C202751555 @default.
• W2400612805 hasConcept C2778260815 @default.
• W2400612805 hasConcept C2780283210 @default.
• W2400612805 hasConcept C55493867 @default.
• W2400612805 hasConcept C62112901 @default.
• W2400612805 hasConcept C62478195 @default.
• W2400612805 hasConcept C86803240 @default.
• W2400612805 hasConcept C95444343 @default.
• W2400612805 hasConceptScore W2400612805C104317684 @default.
• W2400612805 hasConceptScore W2400612805C137620995 @default.
• W2400612805 hasConceptScore W2400612805C153911025 @default.
• W2400612805 hasConceptScore W2400612805C160450060 @default.
• W2400612805 hasConceptScore W2400612805C161879069 @default.
• W2400612805 hasConceptScore W2400612805C173396325 @default.
• W2400612805 hasConceptScore W2400612805C185592680 @default.
• W2400612805 hasConceptScore W2400612805C190283241 @default.
• W2400612805 hasConceptScore W2400612805C202751555 @default.
• W2400612805 hasConceptScore W2400612805C2778260815 @default.
• W2400612805 hasConceptScore W2400612805C2780283210 @default.
• W2400612805 hasConceptScore W2400612805C55493867 @default.
• W2400612805 hasConceptScore W2400612805C62112901 @default.
• W2400612805 hasConceptScore W2400612805C62478195 @default.
• W2400612805 hasConceptScore W2400612805C86803240 @default.
• W2400612805 hasConceptScore W2400612805C95444343 @default.
• W2400612805 hasIssue "1" @default.
• W2400612805 hasLocation W24006128051 @default.
• W2400612805 hasLocation W24006128052 @default.
• W2400612805 hasLocation W24006128053 @default.
• W2400612805 hasLocation W24006128054 @default.
• W2400612805 hasOpenAccess W2400612805 @default.
• W2400612805 hasPrimaryLocation W24006128051 @default.
• W2400612805 hasRelatedWork W1978215356 @default.
• W2400612805 hasRelatedWork W2013084774 @default.
• W2400612805 hasRelatedWork W2020663183 @default.

• next