FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400682009> ?p ?o ?g. }

• W2400682009 endingPage "188" @default.
• W2400682009 startingPage "183" @default.
• W2400682009 abstract "Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in hemostasis and differences in underlying disease processes make it difficult to apply platelet transfusion practices from other patient populations to neonates. Thrombocytopenia is a risk factor for common preterm complications such as intraventricular hemorrhage; however, a causal link has not been established, and platelet transfusions have not been shown to reduce risk of developing intraventricular hemorrhage. Platelet count frequently drives the decision of whether to transfuse platelets, although there is little evidence to demonstrate what a safe platelet nadir is in preterm neonates. Current clinical assays of platelet function often require large sample volumes and are not valid in the setting of thrombocytopenia; however, evaluation of platelet function and/or global hemostasis may aid in the identification of neonates who are at the highest risk of bleeding. Although platelets' primary role is in establishing hemostasis, platelets also carry pro- and antiangiogenic factors in their granules. Aberrant angiogenesis underpins common complications of prematurity including intraventricular hemorrhage and retinopathy of prematurity. In addition, platelets play an important role in host immune defenses. Infectious and inflammatory conditions such as sepsis and necrotizing enterocolitis are commonly associated with late-onset thrombocytopenia in neonates. Severity of thrombocytopenia is correlated with mortality risk. The nature of this association is unclear, but preclinical data suggest that thrombocytopenia contributes to mortality rather than simply being a proxy for disease severity. Neonates are a distinct patient population in whom thrombocytopenia is common. Their unique physiology and associated complications make the risks and benefits of platelet transfusions difficult to understand. The goal of this review was to highlight research areas that need to be addressed to better understand the risks and benefits of platelet transfusions in neonates. Specifically, it will be important to identify neonates at risk of bleeding who would benefit from a platelet transfusion and to determine whether platelet transfusions either abrogate or exacerbate common neonatal complications such as sepsis, chronic lung disease, necrotizing enterocolitis, and retinopathy of prematurity." @default.
• W2400682009 created "2016-06-24" @default.
• W2400682009 creator A5045029316 @default.
• W2400682009 creator A5061112044 @default.
• W2400682009 date "2016-10-01" @default.
• W2400682009 modified "2023-10-10" @default.
• W2400682009 title "Neonatal Platelet Transfusions and Future Areas of Research" @default.
• W2400682009 cites W1025463489 @default.
• W2400682009 cites W1486158853 @default.
• W2400682009 cites W1554240084 @default.
• W2400682009 cites W1638232714 @default.
• W2400682009 cites W1648756109 @default.
• W2400682009 cites W1937618929 @default.
• W2400682009 cites W1972597766 @default.
• W2400682009 cites W1973129306 @default.
• W2400682009 cites W1974780655 @default.
• W2400682009 cites W1976478686 @default.
• W2400682009 cites W1978331458 @default.
• W2400682009 cites W1981031886 @default.
• W2400682009 cites W1983405988 @default.
• W2400682009 cites W1984581378 @default.
• W2400682009 cites W1987668620 @default.
• W2400682009 cites W1989049509 @default.
• W2400682009 cites W1989164587 @default.
• W2400682009 cites W1989382032 @default.
• W2400682009 cites W1999688175 @default.
• W2400682009 cites W1999941614 @default.
• W2400682009 cites W2000958404 @default.
• W2400682009 cites W2003422362 @default.
• W2400682009 cites W2004082997 @default.
• W2400682009 cites W2004439582 @default.
• W2400682009 cites W2005814999 @default.
• W2400682009 cites W2006888985 @default.
• W2400682009 cites W2007992504 @default.
• W2400682009 cites W2008358579 @default.
• W2400682009 cites W2008984777 @default.
• W2400682009 cites W2011905800 @default.
• W2400682009 cites W2012274988 @default.
• W2400682009 cites W2017127297 @default.
• W2400682009 cites W2018492156 @default.
• W2400682009 cites W2026640260 @default.
• W2400682009 cites W2029536644 @default.
• W2400682009 cites W2029965316 @default.
• W2400682009 cites W2031741978 @default.
• W2400682009 cites W2035546454 @default.
• W2400682009 cites W2037099180 @default.
• W2400682009 cites W2046325862 @default.
• W2400682009 cites W2048814723 @default.
• W2400682009 cites W2049977284 @default.
• W2400682009 cites W2051568921 @default.
• W2400682009 cites W2060540480 @default.
• W2400682009 cites W2062270737 @default.
• W2400682009 cites W2078776340 @default.
• W2400682009 cites W2079629625 @default.
• W2400682009 cites W2081669343 @default.
• W2400682009 cites W2082303830 @default.
• W2400682009 cites W2084632335 @default.
• W2400682009 cites W2085100114 @default.
• W2400682009 cites W2094626802 @default.
• W2400682009 cites W2104559631 @default.
• W2400682009 cites W2107794907 @default.
• W2400682009 cites W2122158384 @default.
• W2400682009 cites W2125304335 @default.
• W2400682009 cites W2130870371 @default.
• W2400682009 cites W2133145440 @default.
• W2400682009 cites W2143152020 @default.
• W2400682009 cites W2156847273 @default.
• W2400682009 cites W221909300 @default.
• W2400682009 cites W2274633650 @default.
• W2400682009 cites W2394772701 @default.
• W2400682009 cites W3148465273 @default.
• W2400682009 cites W4213306700 @default.
• W2400682009 cites W4246365437 @default.
• W2400682009 doi "https://doi.org/10.1016/j.tmrv.2016.05.009" @default.
• W2400682009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27282660" @default.
• W2400682009 hasPublicationYear "2016" @default.
• W2400682009 type Work @default.
• W2400682009 sameAs 2400682009 @default.
• W2400682009 citedByCount "31" @default.
• W2400682009 countsByYear W24006820092017 @default.
• W2400682009 countsByYear W24006820092018 @default.
• W2400682009 countsByYear W24006820092019 @default.
• W2400682009 countsByYear W24006820092020 @default.
• W2400682009 countsByYear W24006820092021 @default.
• W2400682009 countsByYear W24006820092022 @default.
• W2400682009 countsByYear W24006820092023 @default.
• W2400682009 crossrefType "journal-article" @default.
• W2400682009 hasAuthorship W2400682009A5045029316 @default.
• W2400682009 hasAuthorship W2400682009A5061112044 @default.
• W2400682009 hasConcept C126322002 @default.
• W2400682009 hasConcept C177713679 @default.
• W2400682009 hasConcept C187212893 @default.
• W2400682009 hasConcept C203014093 @default.
• W2400682009 hasConcept C2776689292 @default.
• W2400682009 hasConcept C2778376644 @default.
• W2400682009 hasConcept C2778384902 @default.
• W2400682009 hasConcept C2778589496 @default.
• W2400682009 hasConcept C2779234561 @default.

• next