Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400694527> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2400694527 endingPage "77" @default.
- W2400694527 startingPage "569" @default.
- W2400694527 abstract "The influence of triethyl lead chloride (TriEL) on the organization of neurofilaments in vivo was studied by indirect immunofluorescence microscopy employing mouse neuroblastoma cells (Neuro-2a). TriEL induces perinuclear coil formation of neurofilaments in those cells. The rearrangements observed are not correlated with significant changes of the microtubular system. Cells in which the microtubular network was stabilized by Taxol treatment prior to incubation with TriEL even show the rearrangement of the neurofilaments. The effect of TriEL is reversible. In vitro, the effect of TriEL on isolated neurofilaments and on filament formation as well as on the structure of preformed filaments was investigated by electron microscopy. If isolated neurofilaments from porcine spinal cord are incubated in the presence of TriEL, they show constrictions and bulges. Additionally, many fragments are seen. If preformed filaments are treated with TriEL, unraveling of fibers into protofilamentous strands is observed. The assembly of neurofilaments in vitro is disturbed in the presence of TriEL. The interaction of TriEL with neurofilaments in vivo is likely to be at least partly responsible for the neurotoxicity of TriEL." @default.
- W2400694527 created "2016-06-24" @default.
- W2400694527 creator A5012621507 @default.
- W2400694527 creator A5069207470 @default.
- W2400694527 creator A5089203723 @default.
- W2400694527 date "1987-01-01" @default.
- W2400694527 modified "2023-10-14" @default.
- W2400694527 title "Influence of triethyl lead on neurofilaments in vivo and in vitro." @default.
- W2400694527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3126465" @default.
- W2400694527 hasPublicationYear "1987" @default.
- W2400694527 type Work @default.
- W2400694527 sameAs 2400694527 @default.
- W2400694527 citedByCount "5" @default.
- W2400694527 countsByYear W24006945272014 @default.
- W2400694527 crossrefType "journal-article" @default.
- W2400694527 hasAuthorship W2400694527A5012621507 @default.
- W2400694527 hasAuthorship W2400694527A5069207470 @default.
- W2400694527 hasAuthorship W2400694527A5089203723 @default.
- W2400694527 hasConcept C12554922 @default.
- W2400694527 hasConcept C142669718 @default.
- W2400694527 hasConcept C1491633281 @default.
- W2400694527 hasConcept C150903083 @default.
- W2400694527 hasConcept C157207234 @default.
- W2400694527 hasConcept C185592680 @default.
- W2400694527 hasConcept C202751555 @default.
- W2400694527 hasConcept C203014093 @default.
- W2400694527 hasConcept C204232928 @default.
- W2400694527 hasConcept C207001950 @default.
- W2400694527 hasConcept C55493867 @default.
- W2400694527 hasConcept C78383274 @default.
- W2400694527 hasConcept C86803240 @default.
- W2400694527 hasConcept C95444343 @default.
- W2400694527 hasConceptScore W2400694527C12554922 @default.
- W2400694527 hasConceptScore W2400694527C142669718 @default.
- W2400694527 hasConceptScore W2400694527C1491633281 @default.
- W2400694527 hasConceptScore W2400694527C150903083 @default.
- W2400694527 hasConceptScore W2400694527C157207234 @default.
- W2400694527 hasConceptScore W2400694527C185592680 @default.
- W2400694527 hasConceptScore W2400694527C202751555 @default.
- W2400694527 hasConceptScore W2400694527C203014093 @default.
- W2400694527 hasConceptScore W2400694527C204232928 @default.
- W2400694527 hasConceptScore W2400694527C207001950 @default.
- W2400694527 hasConceptScore W2400694527C55493867 @default.
- W2400694527 hasConceptScore W2400694527C78383274 @default.
- W2400694527 hasConceptScore W2400694527C86803240 @default.
- W2400694527 hasConceptScore W2400694527C95444343 @default.
- W2400694527 hasIssue "4" @default.
- W2400694527 hasLocation W24006945271 @default.
- W2400694527 hasOpenAccess W2400694527 @default.
- W2400694527 hasPrimaryLocation W24006945271 @default.
- W2400694527 hasRelatedWork W1982922864 @default.
- W2400694527 hasRelatedWork W2004086215 @default.
- W2400694527 hasRelatedWork W2031662020 @default.
- W2400694527 hasRelatedWork W2034634092 @default.
- W2400694527 hasRelatedWork W2066858262 @default.
- W2400694527 hasRelatedWork W2077168882 @default.
- W2400694527 hasRelatedWork W2143587767 @default.
- W2400694527 hasRelatedWork W2622510373 @default.
- W2400694527 hasRelatedWork W4244975551 @default.
- W2400694527 hasRelatedWork W636460937 @default.
- W2400694527 hasVolume "8" @default.
- W2400694527 isParatext "false" @default.
- W2400694527 isRetracted "false" @default.
- W2400694527 magId "2400694527" @default.
- W2400694527 workType "article" @default.