FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400699574> ?p ?o ?g. }

• W2400699574 endingPage "5758" @default.
• W2400699574 startingPage "5750" @default.
• W2400699574 abstract "ABSTRACT African green monkeys (AGMs) are natural hosts of simian immunodeficiency virus (SIV AGM ). Because these animals do not develop simian AIDS despite maintaining high viral loads, there is considerable interest in determining how these animals have evolved to avoid SIV disease progression. Unlike nonnatural hosts of SIV, adult AGMs maintain low levels of CD4 + T cells at steady states and also have a large population of virus-resistant CD8αα T cells that lack CD4 expression despite maintaining T helper cell functionalities. In recent work, we have shown that homeostatic cytokines can induce CD4 downregulation in AGM T cells in vitro . Through administering therapeutic doses of recombinant human interleukin-2 (IL-2) to AGMs, we show here that this mechanism is operative in vivo . IL-2 therapy induced transient yet robust proliferation in all major T cell subsets. Within the CD4 + T cell population, those that were induced into cycle by IL-2 exhibited characteristics of CD4-to-CD8αα conversion. In all animals receiving IL-2, circulating CD4 + T cell counts and proportions tended to be lower and CD4 − CD8αα + T cell counts tended to be higher. Despite reductions in circulating target cells, the viral load was unaffected over the course of study. IMPORTANCE The data in this study identify that homeostatic cytokines can downregulate CD4 in vivo and, when given therapeutically, can induce AGMs to sustain very low levels of circulating CD4 + T cells without showing signs of immunodeficiency." @default.
• W2400699574 created "2016-06-24" @default.
• W2400699574 creator A5001625829 @default.
• W2400699574 creator A5009812327 @default.
• W2400699574 creator A5016013383 @default.
• W2400699574 creator A5054243164 @default.
• W2400699574 creator A5088067567 @default.
• W2400699574 date "2016-06-15" @default.
• W2400699574 modified "2023-10-11" @default.
• W2400699574 title "Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys" @default.
• W2400699574 cites W1919948406 @default.
• W2400699574 cites W1974723750 @default.
• W2400699574 cites W1985126564 @default.
• W2400699574 cites W1995358925 @default.
• W2400699574 cites W1996128058 @default.
• W2400699574 cites W2002051431 @default.
• W2400699574 cites W2003121559 @default.
• W2400699574 cites W2026836824 @default.
• W2400699574 cites W2038797605 @default.
• W2400699574 cites W2048663097 @default.
• W2400699574 cites W2054212413 @default.
• W2400699574 cites W2064783820 @default.
• W2400699574 cites W2089613017 @default.
• W2400699574 cites W2102455459 @default.
• W2400699574 cites W2104586170 @default.
• W2400699574 cites W2105548633 @default.
• W2400699574 cites W2108743658 @default.
• W2400699574 cites W2121012709 @default.
• W2400699574 cites W2128720756 @default.
• W2400699574 cites W2148000177 @default.
• W2400699574 cites W2151817796 @default.
• W2400699574 cites W2156964052 @default.
• W2400699574 cites W2162030910 @default.
• W2400699574 cites W2164265306 @default.
• W2400699574 cites W2164701887 @default.
• W2400699574 cites W2166122762 @default.
• W2400699574 cites W2167148984 @default.
• W2400699574 cites W2169114649 @default.
• W2400699574 cites W2322140879 @default.
• W2400699574 cites W2394576951 @default.
• W2400699574 cites W2955504961 @default.
• W2400699574 doi "https://doi.org/10.1128/jvi.00057-16" @default.
• W2400699574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4886792" @default.
• W2400699574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27053558" @default.
• W2400699574 hasPublicationYear "2016" @default.
• W2400699574 type Work @default.
• W2400699574 sameAs 2400699574 @default.
• W2400699574 citedByCount "3" @default.
• W2400699574 countsByYear W24006995742020 @default.
• W2400699574 countsByYear W24006995742022 @default.
• W2400699574 countsByYear W24006995742023 @default.
• W2400699574 crossrefType "journal-article" @default.
• W2400699574 hasAuthorship W2400699574A5001625829 @default.
• W2400699574 hasAuthorship W2400699574A5009812327 @default.
• W2400699574 hasAuthorship W2400699574A5016013383 @default.
• W2400699574 hasAuthorship W2400699574A5054243164 @default.
• W2400699574 hasAuthorship W2400699574A5088067567 @default.
• W2400699574 hasBestOaLocation W24006995741 @default.
• W2400699574 hasConcept C104317684 @default.
• W2400699574 hasConcept C127561419 @default.
• W2400699574 hasConcept C142462285 @default.
• W2400699574 hasConcept C150903083 @default.
• W2400699574 hasConcept C154317977 @default.
• W2400699574 hasConcept C159047783 @default.
• W2400699574 hasConcept C167672396 @default.
• W2400699574 hasConcept C202751555 @default.
• W2400699574 hasConcept C203014093 @default.
• W2400699574 hasConcept C207001950 @default.
• W2400699574 hasConcept C2522874641 @default.
• W2400699574 hasConcept C26291073 @default.
• W2400699574 hasConcept C2776090121 @default.
• W2400699574 hasConcept C2777371288 @default.
• W2400699574 hasConcept C2777995582 @default.
• W2400699574 hasConcept C2778690821 @default.
• W2400699574 hasConcept C2908647359 @default.
• W2400699574 hasConcept C55493867 @default.
• W2400699574 hasConcept C71924100 @default.
• W2400699574 hasConcept C74172505 @default.
• W2400699574 hasConcept C86803240 @default.
• W2400699574 hasConcept C8891405 @default.
• W2400699574 hasConcept C98119934 @default.
• W2400699574 hasConcept C99454951 @default.
• W2400699574 hasConceptScore W2400699574C104317684 @default.
• W2400699574 hasConceptScore W2400699574C127561419 @default.
• W2400699574 hasConceptScore W2400699574C142462285 @default.
• W2400699574 hasConceptScore W2400699574C150903083 @default.
• W2400699574 hasConceptScore W2400699574C154317977 @default.
• W2400699574 hasConceptScore W2400699574C159047783 @default.
• W2400699574 hasConceptScore W2400699574C167672396 @default.
• W2400699574 hasConceptScore W2400699574C202751555 @default.
• W2400699574 hasConceptScore W2400699574C203014093 @default.
• W2400699574 hasConceptScore W2400699574C207001950 @default.
• W2400699574 hasConceptScore W2400699574C2522874641 @default.
• W2400699574 hasConceptScore W2400699574C26291073 @default.
• W2400699574 hasConceptScore W2400699574C2776090121 @default.
• W2400699574 hasConceptScore W2400699574C2777371288 @default.
• W2400699574 hasConceptScore W2400699574C2777995582 @default.
• W2400699574 hasConceptScore W2400699574C2778690821 @default.

• next