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- W2400762211 abstract "Background: Erythroderma, a generalized exfoliative dermatitis, is a rare but easily recognized skin condition with the potential for serious outcomes. Various conditions may be associated with the development of erythroderma. Objective: The purpose of this study was to evaluate the prevalence, clinical, laboratory, histopathological findings and evolution of erythroderma and classify the various causes of the disease. Methods: We reviewed medical records, skin biopsy results and clinical photos of 75 patients diagnosed with erythroderma from 1984 to 2006. Results: The male-female ratio was 2.4：1. The mean age at diagnosis was 57 years. 26 out of 75 patients (34.7%) had a history of drug ingestion and a preexisting dermatosis. Nineteen patients (25.3%) remained undetermined. Four patients (5.3%) had concomitant malignancies. In the dermatosis induced group, 10 patients (38.4%) had psoriasis as a possible causative dermatologic disease. Fever (≥38oC) was seen in 28% of patients. Laboratory abnormalities were seen in the order of leukocytosis, eosinophilia, elevated IgE level (＞500 IU/ml), elevated erythrocyte sedimentation rate (ESR), elevated lactate dehydrogenase (LDH). There was a significant difference in the proportion of patients showing complete remission to treatment among the groups. In the group of patients who had a recent history of drug ingestion, 42% of patients showed complete remission, whereas the remaining groups, especially the group with preexisting dermatosis displayed only 8% of cases resulting in complete remission (p＜0.05). Conclusion: In our view, drug use or pre-existing dermatosis induced erythroderma compose the majority of cases. The differences in response rates among groups may give a more realistic estimation of clinical outcome and provide appropriate guidance to clinicians. (Korean J Dermatol 2008;46(2):202∼208)" @default.
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- W2400762211 date "2008-01-01" @default.
- W2400762211 modified "2023-09-24" @default.
- W2400762211 title "A Clinico-epidemiologic Study of 75 Cases of Erythroderma" @default.
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