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- W2400767568 abstract "During the past five years over 500 patients with chest infections treated with TMP/SMX combinations have been studied. Most of the patients had chronic bronchitis and were treated during acute exacerbations. The most common pathogenic organisms grown from the sputum were Haemophilus influenzae and Streptococcus pneumoniae. A single-blind comparative trial with ampicillin in a dosage of 2 gm/day was undertaken, which showed that Septrin was more effective in reducing sputum volume and purulence, and in eradicating pathogens from the sputum. Two groups of patients with severe bronchitis received the combination for periods of between three and 30 months. The clinical effect was excellent, and effects on the blood count minimal. No strain of Haemophilus influenzas or Streptococcus pneumoniae emerged that was resistant to the combination. Other lung infections successfully treated included pneumonia (15 cases), lung abscess (three cases), and bronchiectasis (six cases). Pathogenic organisms eradicated from the sputum included penicillin-resistant Staphylococci and Klebsiella. Trimethoprim is concentrated in the sputum, which may account for the efficacy of the combination in treating chest infections." @default.
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- W2400767568 date "1973-02-01" @default.
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- W2400767568 title "USE OF COMBINATIONS OF TRIMETHOPRIM AND SULPHAMETHOXAZOLE IN THE TREATMENT OF CHEST INFECTIONS" @default.
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- W2400767568 doi "https://doi.org/10.5694/j.1326-5377.1973.tb111191.x" @default.
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