Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400777310> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2400777310 endingPage "87" @default.
- W2400777310 startingPage "374" @default.
- W2400777310 abstract "Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome appear as the same expression of thrombotic microangiopathy (TMA), which is a single pathological entity affecting small blood vessels leading to hemolytic anemia, circulatory changes with renal (hemolytic uremic syndrome, HUS) or nervous (thrombotic thrombocytopenic purpura, TTP) involvement. Because of his low incidence, prospective randomized clinical trials are difficult to conduct and apart from plasma exchanges (PE) which appear superior to plasma infusions (PI), other therapeutic recommendations are based on retrospective studies or on anecdotal reports with limited number of patients. In the absence of appropriate therapy, mortality rate was initially above 90% in adults with TTP. Plasma infusions and plasma exchanges have dramatically improved prognosis of the disease, since more than 80% of patients respond to therapy with a survival greater than 80 to 90%. Analysis of data of medical literature shows that plasma exchanges can cure 82% of TMA with 15% of refractory TMA and a mortality rate of 14%. In two randomized trials, PE are more effective than PI with a response rate benefit of 25% and an overall survival increase of 15%. Although severe thrombocytopenia is frequently observed, it is important to avoid platelet transfusions. Platelets infusions induce deleterious effects since they add to the severity and the extend of microvascular thrombi formation. Use of glucocorticoids, heparin, antiplatelet therapy, intravenous immunoglobulin and vincristine are associated with variable results and no controlled study supports their use. Splenectomy is still under discussion but could be of interest in case of relapsing thrombotic microangiopathies as an attempt to reduce the rate of TMA recurrence." @default.
- W2400777310 created "2016-06-24" @default.
- W2400777310 creator A5010704051 @default.
- W2400777310 creator A5030724329 @default.
- W2400777310 creator A5051507920 @default.
- W2400777310 creator A5061823012 @default.
- W2400777310 creator A5072996306 @default.
- W2400777310 date "1999-09-01" @default.
- W2400777310 modified "2023-10-15" @default.
- W2400777310 title "[Treatment of thrombotic microangiopathies]." @default.
- W2400777310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10544747" @default.
- W2400777310 hasPublicationYear "1999" @default.
- W2400777310 type Work @default.
- W2400777310 sameAs 2400777310 @default.
- W2400777310 citedByCount "2" @default.
- W2400777310 countsByYear W24007773102022 @default.
- W2400777310 crossrefType "journal-article" @default.
- W2400777310 hasAuthorship W2400777310A5010704051 @default.
- W2400777310 hasAuthorship W2400777310A5030724329 @default.
- W2400777310 hasAuthorship W2400777310A5051507920 @default.
- W2400777310 hasAuthorship W2400777310A5061823012 @default.
- W2400777310 hasAuthorship W2400777310A5072996306 @default.
- W2400777310 hasConcept C126322002 @default.
- W2400777310 hasConcept C134018914 @default.
- W2400777310 hasConcept C179755657 @default.
- W2400777310 hasConcept C203014093 @default.
- W2400777310 hasConcept C2776175824 @default.
- W2400777310 hasConcept C2776283816 @default.
- W2400777310 hasConcept C2776309230 @default.
- W2400777310 hasConcept C2776513394 @default.
- W2400777310 hasConcept C2776694085 @default.
- W2400777310 hasConcept C2776755627 @default.
- W2400777310 hasConcept C2777878052 @default.
- W2400777310 hasConcept C2778585876 @default.
- W2400777310 hasConcept C2779134260 @default.
- W2400777310 hasConcept C2779429289 @default.
- W2400777310 hasConcept C2780931953 @default.
- W2400777310 hasConcept C2781127562 @default.
- W2400777310 hasConcept C555293320 @default.
- W2400777310 hasConcept C66112548 @default.
- W2400777310 hasConcept C71924100 @default.
- W2400777310 hasConcept C89560881 @default.
- W2400777310 hasConcept C90924648 @default.
- W2400777310 hasConceptScore W2400777310C126322002 @default.
- W2400777310 hasConceptScore W2400777310C134018914 @default.
- W2400777310 hasConceptScore W2400777310C179755657 @default.
- W2400777310 hasConceptScore W2400777310C203014093 @default.
- W2400777310 hasConceptScore W2400777310C2776175824 @default.
- W2400777310 hasConceptScore W2400777310C2776283816 @default.
- W2400777310 hasConceptScore W2400777310C2776309230 @default.
- W2400777310 hasConceptScore W2400777310C2776513394 @default.
- W2400777310 hasConceptScore W2400777310C2776694085 @default.
- W2400777310 hasConceptScore W2400777310C2776755627 @default.
- W2400777310 hasConceptScore W2400777310C2777878052 @default.
- W2400777310 hasConceptScore W2400777310C2778585876 @default.
- W2400777310 hasConceptScore W2400777310C2779134260 @default.
- W2400777310 hasConceptScore W2400777310C2779429289 @default.
- W2400777310 hasConceptScore W2400777310C2780931953 @default.
- W2400777310 hasConceptScore W2400777310C2781127562 @default.
- W2400777310 hasConceptScore W2400777310C555293320 @default.
- W2400777310 hasConceptScore W2400777310C66112548 @default.
- W2400777310 hasConceptScore W2400777310C71924100 @default.
- W2400777310 hasConceptScore W2400777310C89560881 @default.
- W2400777310 hasConceptScore W2400777310C90924648 @default.
- W2400777310 hasIssue "5" @default.
- W2400777310 hasLocation W24007773101 @default.
- W2400777310 hasOpenAccess W2400777310 @default.
- W2400777310 hasPrimaryLocation W24007773101 @default.
- W2400777310 hasRelatedWork W1969018345 @default.
- W2400777310 hasRelatedWork W1992793867 @default.
- W2400777310 hasRelatedWork W2034225516 @default.
- W2400777310 hasRelatedWork W2397835201 @default.
- W2400777310 hasRelatedWork W2406557103 @default.
- W2400777310 hasRelatedWork W2470736157 @default.
- W2400777310 hasRelatedWork W2772410375 @default.
- W2400777310 hasRelatedWork W3164366871 @default.
- W2400777310 hasRelatedWork W3187781154 @default.
- W2400777310 hasRelatedWork W2184907049 @default.
- W2400777310 hasVolume "150" @default.
- W2400777310 isParatext "false" @default.
- W2400777310 isRetracted "false" @default.
- W2400777310 magId "2400777310" @default.
- W2400777310 workType "article" @default.