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- W2400805990 abstract "To investigate the effect of morphine preconditioning on mitochondrial permeability transition pore (MPTP) and its protective mechanism after myocardial ischemia-reperfusion injury.A rat model of ischemia-reperfusion injury was established. Forty rats were injected with 2-(3)[H] DOG and then divided into 4 groups randomly: a sham operation (S) group, an ischemia-reperfusion injury (IR) group, a morphine preconditioning (Mp+IR) group, and a cyclosporine A preconditioning (CsA+IR) group. We monitored the concentrations of serum creatine kinase-Mb (CK-Mb) and cardiac troponin I (cTnI), and measured myocardial mitochondrial 2-(3)[H] DOG, cytochrome c content, Ca(2+) concentration ([Ca(2+)]m), the velocity of Ca(2+) intake and reaction half time of mitochondrial permeability transition pore (MPTP t(1/2)) in the 4 groups.The concentrations of serum CK-Mb and cTnI decreased more in the Mp+IR group and the CsA+IR group than those of the IR group. The concentrations of 2-(3)[H]DOG and [Ca(2+)]m in the IR group were evidently higher but the level of cytochrome c was lower than those of the sham operation group. The concentrations of 2-(3)[H] DOG and [Ca(2+)]m in the Mp+IR group decreased whereas the concentration of cytochrome c increased compared with those in the IR group. Mitochondrial 2-(3)[H]DOG content was positively correlated with the concentration of calcium (r=0.797, P<0.01). The 2-(3)[H]DOG and [Ca(2+)]m content were negatively correlated with cytochrome c in the IR group (r=-0.805 and r=-0.648, respectively, P<0.01). MPTP t(1/2) in the IR group was shortened evidently, and that in the Mp+IR and CsA+IR group was significantly lengthened.Morphine preconditioning may have myocardial protective effect through unburdening the calcium overload and lengthening the MPTP t(1/2)." @default.
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- W2400805990 date "2010-08-01" @default.
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- W2400805990 title "Effect of morphine preconditioning on mitochondrial permeability transition pore after myocardial ischemia-reperfusion injury in rats." @default.
- W2400805990 doi "https://doi.org/10.3969/j.issn.1672-7347.2010.08.005" @default.
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