Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400807003> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2400807003 endingPage "73" @default.
- W2400807003 startingPage "363" @default.
- W2400807003 abstract "To determine mechanisms that trigger graft vascular disease (GVD) after heart transplantation, we studied parameters that reflect both early and late intragraft allogeneic reactions.With reverse transcriptase-polymerase chain reaction analysis, mRNA expression of interleukin-2 (IL-2), interleukin-4, interleukin-6, interleukin-10, interferon-gamma, platelet-derived growth factor-alpha, and transforming growth factor-beta was measured in endomyocardial biopsy (EMB) specimens obtained from 34 recipients during the first acute rejection episode (n = 29) or at a comparable time after transplantation for patients without rejection (n = 5) and at time of assessment of GVD by coronary angiography at 1 year (n = 34).At the time of assessment of GVD, mRNA expression of IL-2, interleukin-4, and interleukin-6 were barely detectable, whereas messenger coding for interferon-gamma, interleukin-10, transforming growth factor-beta, and platelet-derived growth factor-alpha genes were constitutively expressed. Moreover, intragraft mRNA patterns of cytokines and growth factors between patients with GVD (n = 17) or without GVD (n = 17) were comparable. In contrast, during the first acute rejection episode a completely different pattern was found. Development of GVD was associated with IL-2 mRNA expression and not with the other cytokines analyzed. IL-2 mRNA was present in 77% of rejection EMB specimens obtained from patients with GVD versus 33% of the EMB specimens obtained from patients without GVD (p = 0.03) and not detectable in EMB specimens obtained from patients with no rejection. Also nonimmunologic risk factors such as longer ischemia time (median 193 vs 141 minutes; p = 0.002) and higher donor age (median 32 vs 23 years; p = 0.02) were associated with GVD. But no relation was found between these nonimmunologic risk factors and IL-2-positive acute rejections.Nonspecific risk factors and IL-2-positive rejections may independently trigger GVD after clinical heart transplantation." @default.
- W2400807003 created "2016-06-24" @default.
- W2400807003 creator A5000354857 @default.
- W2400807003 creator A5002547849 @default.
- W2400807003 creator A5004434511 @default.
- W2400807003 creator A5008497236 @default.
- W2400807003 creator A5011538150 @default.
- W2400807003 creator A5059207871 @default.
- W2400807003 creator A5067828032 @default.
- W2400807003 creator A5083821618 @default.
- W2400807003 creator A5091596437 @default.
- W2400807003 date "1998-04-01" @default.
- W2400807003 modified "2023-09-23" @default.
- W2400807003 title "The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantation." @default.
- W2400807003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9588581" @default.
- W2400807003 hasPublicationYear "1998" @default.
- W2400807003 type Work @default.
- W2400807003 sameAs 2400807003 @default.
- W2400807003 citedByCount "18" @default.
- W2400807003 crossrefType "journal-article" @default.
- W2400807003 hasAuthorship W2400807003A5000354857 @default.
- W2400807003 hasAuthorship W2400807003A5002547849 @default.
- W2400807003 hasAuthorship W2400807003A5004434511 @default.
- W2400807003 hasAuthorship W2400807003A5008497236 @default.
- W2400807003 hasAuthorship W2400807003A5011538150 @default.
- W2400807003 hasAuthorship W2400807003A5059207871 @default.
- W2400807003 hasAuthorship W2400807003A5067828032 @default.
- W2400807003 hasAuthorship W2400807003A5083821618 @default.
- W2400807003 hasAuthorship W2400807003A5091596437 @default.
- W2400807003 hasConcept C104317684 @default.
- W2400807003 hasConcept C105580179 @default.
- W2400807003 hasConcept C126322002 @default.
- W2400807003 hasConcept C142724271 @default.
- W2400807003 hasConcept C170493617 @default.
- W2400807003 hasConcept C2775960820 @default.
- W2400807003 hasConcept C2778690821 @default.
- W2400807003 hasConcept C2778849806 @default.
- W2400807003 hasConcept C2911091166 @default.
- W2400807003 hasConcept C55493867 @default.
- W2400807003 hasConcept C71924100 @default.
- W2400807003 hasConcept C74172505 @default.
- W2400807003 hasConcept C86803240 @default.
- W2400807003 hasConceptScore W2400807003C104317684 @default.
- W2400807003 hasConceptScore W2400807003C105580179 @default.
- W2400807003 hasConceptScore W2400807003C126322002 @default.
- W2400807003 hasConceptScore W2400807003C142724271 @default.
- W2400807003 hasConceptScore W2400807003C170493617 @default.
- W2400807003 hasConceptScore W2400807003C2775960820 @default.
- W2400807003 hasConceptScore W2400807003C2778690821 @default.
- W2400807003 hasConceptScore W2400807003C2778849806 @default.
- W2400807003 hasConceptScore W2400807003C2911091166 @default.
- W2400807003 hasConceptScore W2400807003C55493867 @default.
- W2400807003 hasConceptScore W2400807003C71924100 @default.
- W2400807003 hasConceptScore W2400807003C74172505 @default.
- W2400807003 hasConceptScore W2400807003C86803240 @default.
- W2400807003 hasIssue "4" @default.
- W2400807003 hasLocation W24008070031 @default.
- W2400807003 hasOpenAccess W2400807003 @default.
- W2400807003 hasPrimaryLocation W24008070031 @default.
- W2400807003 hasRelatedWork W1987303012 @default.
- W2400807003 hasRelatedWork W1992788236 @default.
- W2400807003 hasRelatedWork W2013289616 @default.
- W2400807003 hasRelatedWork W2021633591 @default.
- W2400807003 hasRelatedWork W2022499899 @default.
- W2400807003 hasRelatedWork W2077829725 @default.
- W2400807003 hasRelatedWork W2088459355 @default.
- W2400807003 hasRelatedWork W2376071734 @default.
- W2400807003 hasRelatedWork W2381700890 @default.
- W2400807003 hasRelatedWork W4241732276 @default.
- W2400807003 hasVolume "17" @default.
- W2400807003 isParatext "false" @default.
- W2400807003 isRetracted "false" @default.
- W2400807003 magId "2400807003" @default.
- W2400807003 workType "article" @default.