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- W2400821406 abstract "Abstract Hemoglobin beta Knossos (beta 27Ala-Ser) is a cause of beta-thalassemia due to its reduced synthesis. To investigate the basis for this observation, we have isolated the beta Knossos gene and examined its expression in heterologous cells. We have found that some beta Knossos RNA transcripts are abnormally processed, utilizing a cryptic splice sequence that is enhanced by the Knossos substitution. This form of abnormal RNA processing is seen in two other mutations in this region (a silent substitution in codon 24 and the substitution in codon 26 that produces the beta E variant) and most likely contributes appreciably to the reduced synthesis of beta Knossos." @default.
- W2400821406 created "2016-06-24" @default.
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- W2400821406 date "1984-07-01" @default.
- W2400821406 modified "2023-10-16" @default.
- W2400821406 title "Abnormal processing of beta Knossos RNA" @default.
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- W2400821406 doi "https://doi.org/10.1182/blood.v64.1.311.311" @default.
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