Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400854136> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2400854136 endingPage "12" @default.
- W2400854136 startingPage "509" @default.
- W2400854136 abstract "To explore the somatic mutations of PIG-A gene in Chinese patients with paroxysmal nocturnal hemoglobinuria (PNH) and to compare these mutations with those in non-Chinese PNH patients.Seven overlapping regions of PIG-A cDNA from granulocytes of 4 PNH patients were amplified by RT-PCR. The mutant segments were identified by HA/SSCP and then cloned and sequenced.In 4 Chinese PNH patients five small PIG-A mutations were found, including four single base substitutions (resulting in 1 consense mutations and 3 missense mutations) and one single base deletion causing a frameshift). These mutations were all different and distributed in different locations of the gene.The PIG-A mutations in our patients occurred at random sites and no mutation hot spot was found. Compared with Japanese, British, American and Tai patients, Chinese patients seem to have more single base substitutions and less frameshift. The pattern of mutations in our patients is similar to that in Japanese patients but different from that in other races. These suggest that mutagens might be different in the pathogenesis of PNH in different regions." @default.
- W2400854136 created "2016-06-24" @default.
- W2400854136 creator A5008052115 @default.
- W2400854136 creator A5024433878 @default.
- W2400854136 creator A5058087620 @default.
- W2400854136 date "1997-10-01" @default.
- W2400854136 modified "2023-09-26" @default.
- W2400854136 title "[Somatic mutations of PIG-A gene in Chinese patients with paroxysmal nocturnal hemoglobinuria]." @default.
- W2400854136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15625823" @default.
- W2400854136 hasPublicationYear "1997" @default.
- W2400854136 type Work @default.
- W2400854136 sameAs 2400854136 @default.
- W2400854136 citedByCount "0" @default.
- W2400854136 crossrefType "journal-article" @default.
- W2400854136 hasAuthorship W2400854136A5008052115 @default.
- W2400854136 hasAuthorship W2400854136A5024433878 @default.
- W2400854136 hasAuthorship W2400854136A5058087620 @default.
- W2400854136 hasConcept C104317684 @default.
- W2400854136 hasConcept C13514818 @default.
- W2400854136 hasConcept C203014093 @default.
- W2400854136 hasConcept C2777346216 @default.
- W2400854136 hasConcept C29906990 @default.
- W2400854136 hasConcept C501734568 @default.
- W2400854136 hasConcept C54355233 @default.
- W2400854136 hasConcept C75563809 @default.
- W2400854136 hasConcept C86803240 @default.
- W2400854136 hasConceptScore W2400854136C104317684 @default.
- W2400854136 hasConceptScore W2400854136C13514818 @default.
- W2400854136 hasConceptScore W2400854136C203014093 @default.
- W2400854136 hasConceptScore W2400854136C2777346216 @default.
- W2400854136 hasConceptScore W2400854136C29906990 @default.
- W2400854136 hasConceptScore W2400854136C501734568 @default.
- W2400854136 hasConceptScore W2400854136C54355233 @default.
- W2400854136 hasConceptScore W2400854136C75563809 @default.
- W2400854136 hasConceptScore W2400854136C86803240 @default.
- W2400854136 hasIssue "10" @default.
- W2400854136 hasLocation W24008541361 @default.
- W2400854136 hasOpenAccess W2400854136 @default.
- W2400854136 hasPrimaryLocation W24008541361 @default.
- W2400854136 hasRelatedWork W129719438 @default.
- W2400854136 hasRelatedWork W151118185 @default.
- W2400854136 hasRelatedWork W2023114807 @default.
- W2400854136 hasRelatedWork W2040337396 @default.
- W2400854136 hasRelatedWork W2046016814 @default.
- W2400854136 hasRelatedWork W2171148788 @default.
- W2400854136 hasRelatedWork W2202189920 @default.
- W2400854136 hasRelatedWork W2233073363 @default.
- W2400854136 hasRelatedWork W2361359827 @default.
- W2400854136 hasRelatedWork W2365232955 @default.
- W2400854136 hasRelatedWork W2370484967 @default.
- W2400854136 hasRelatedWork W2410543431 @default.
- W2400854136 hasRelatedWork W2434359381 @default.
- W2400854136 hasRelatedWork W2463846230 @default.
- W2400854136 hasRelatedWork W2550729355 @default.
- W2400854136 hasRelatedWork W2984708587 @default.
- W2400854136 hasRelatedWork W2998049826 @default.
- W2400854136 hasRelatedWork W3022532040 @default.
- W2400854136 hasRelatedWork W3146528660 @default.
- W2400854136 hasRelatedWork W2187752375 @default.
- W2400854136 hasVolume "18" @default.
- W2400854136 isParatext "false" @default.
- W2400854136 isRetracted "false" @default.
- W2400854136 magId "2400854136" @default.
- W2400854136 workType "article" @default.