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- W2400879969 abstract "Purpose . Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods . CYBA gene<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results . The frequency of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp.,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.020</mml:mn></mml:math>), as well as the frequency of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G allele (62.2% versus 54.0%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.009</mml:mn></mml:math>). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08–1.83 for<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G versus <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49A). Carrier state of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50–13.20,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.002</mml:mn></mml:math>), as well as the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G allele (OR = 2.25, 95% CI: 1.34–3.77,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.001</mml:mn></mml:math>). The<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.015</mml:mn></mml:math>). Conclusion . The CYBA gene<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:mrow></mml:math>49A>G polymorphism modifies the risk of coronary artery disease." @default.
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- W2400879969 title "TheCYBAGene⁎49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease" @default.
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- W2400879969 doi "https://doi.org/10.1155/2016/1539671" @default.
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