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• W2400897667 abstract "Objectives To investigate the effect and the mechanism of anti-tumor agent hydroxycamptothecin (HCPT) on HeLa cells in cervical cancer. Materials and methods Autophagy and apoptosis were detected by western blotting and the transfection of GFP-LC3 shRNA as well as Hoechst staining. Results The authors found that the expression of the regulators of Beclin-1, p62, and microtubule-associated protein 1 light chain 3 (LC3) upregulated and then triggered the occurrence of cell autophagy. On the other hand, HCPT could induce to the formation of autophagy and resulted in cell apoptosis after autophagy. Conclusion HCPT can alter cell autophagy and then trigger cell apoptosis to achieve antitumor effects." @default.
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• W2400897667 date "2016-04-10" @default.
• W2400897667 modified "2023-09-28" @default.
• W2400897667 title "Hydroxycamptothecin shows antitumor efficacy on HeLa cells via autophagy activation mediated apoptosis in cervical cancer" @default.
• W2400897667 doi "https://doi.org/10.12892/ejgo2845.2016" @default.
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