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- W2401004328 endingPage "780" @default.
- W2401004328 startingPage "767" @default.
- W2401004328 abstract "Multidrug-resistant (MDR) bacteria, particularly Gram negatives, such as Enterobacteriaceae resistant to third-generation cephalosporins or carbapenems and MDR Pseudomonas aeruginosa, are increasingly frequent in hematology patients. The prevalence of different resistant species varies significantly between centers. Thus, the knowledge of local epidemiology is mandatory for deciding the most appr-opriate management protocols. In the era of increasing antibiotic resistance, empirical therapy of febrile neutropenia should be individualized. A de-escalation approach is recommended in case of severe clinical presentation in patients who are at high risk for infection with a resistant strain. Targeted therapy of an MDR Gram negative usually calls for a combination treatment, although no large randomized trials exist in this setting. Infection control measures are the cornerstone of limiting the spread of MDR pathogens in hematology units." @default.
- W2401004328 created "2016-06-24" @default.
- W2401004328 creator A5027822838 @default.
- W2401004328 creator A5066405827 @default.
- W2401004328 date "2016-06-01" @default.
- W2401004328 modified "2023-09-26" @default.
- W2401004328 title "Multidrug-resistant bacteria in hematology patients: emerging threats" @default.
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- W2401004328 doi "https://doi.org/10.2217/fmb-2015-0014" @default.