Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401032354> ?p ?o ?g. }
- W2401032354 abstract "Copy number variation (CNV) represents an important source of genetic divergence that can produce drastic phenotypic differences and may therefore be subject to selection during domestication and environmental adaptation. To investigate the evolutionary dynamics of CNV in the yak genome, we used a read depth approach to detect CNV based on genome resequencing data from 14 wild and 65 domestic yaks and determined CNV regions related to domestication and adaptations to high-altitude.We identified 2,634 CNV regions (CNVRs) comprising a total of 153 megabases (5.7 % of the yak genome) and 3,879 overlapping annotated genes. Comparison between domestic and wild yak populations identified 121 potentially selected CNVRs, harboring genes related to neuronal development, reproduction, nutrition and energy metabolism. In addition, we found 85 CNVRs that are significantly different between domestic yak living in high- and low-altitude areas, including three genes related to hypoxia response and six related to immune defense. This analysis shows that genic CNVs may play an important role in phenotypic changes during yak domestication and adaptation to life at high-altitude.We present the first refined CNV map for yak along with comprehensive genomic analysis of yak CNV. Our results provide new insights into the genetic basis of yak domestication and adaptation to living in a high-altitude environment, as well as a valuable genetic resource that will facilitate future CNV association studies of important traits in yak and other bovid species." @default.
- W2401032354 created "2016-06-24" @default.
- W2401032354 creator A5005678061 @default.
- W2401032354 creator A5012088837 @default.
- W2401032354 creator A5015080202 @default.
- W2401032354 creator A5019504575 @default.
- W2401032354 creator A5027518890 @default.
- W2401032354 creator A5030691366 @default.
- W2401032354 creator A5034853997 @default.
- W2401032354 creator A5057828493 @default.
- W2401032354 creator A5081281820 @default.
- W2401032354 creator A5090769445 @default.
- W2401032354 date "2016-05-20" @default.
- W2401032354 modified "2023-10-18" @default.
- W2401032354 title "Genome-wide patterns of copy number variation in the Chinese yak genome" @default.
- W2401032354 cites W1546258006 @default.
- W2401032354 cites W1607363557 @default.
- W2401032354 cites W1964111853 @default.
- W2401032354 cites W1965035453 @default.
- W2401032354 cites W1966097738 @default.
- W2401032354 cites W1968422847 @default.
- W2401032354 cites W1969615213 @default.
- W2401032354 cites W1971580911 @default.
- W2401032354 cites W1971898231 @default.
- W2401032354 cites W1973067702 @default.
- W2401032354 cites W1973149643 @default.
- W2401032354 cites W1977314055 @default.
- W2401032354 cites W1980856647 @default.
- W2401032354 cites W1981873490 @default.
- W2401032354 cites W1992722091 @default.
- W2401032354 cites W1995538276 @default.
- W2401032354 cites W1995744312 @default.
- W2401032354 cites W1997538720 @default.
- W2401032354 cites W1999652376 @default.
- W2401032354 cites W1999858501 @default.
- W2401032354 cites W2000875498 @default.
- W2401032354 cites W2001076144 @default.
- W2401032354 cites W2001338440 @default.
- W2401032354 cites W2002630594 @default.
- W2401032354 cites W2003367727 @default.
- W2401032354 cites W2006331098 @default.
- W2401032354 cites W2012151892 @default.
- W2401032354 cites W2013976859 @default.
- W2401032354 cites W2016168964 @default.
- W2401032354 cites W2021714239 @default.
- W2401032354 cites W2033488088 @default.
- W2401032354 cites W2034197594 @default.
- W2401032354 cites W2040980696 @default.
- W2401032354 cites W2045040686 @default.
- W2401032354 cites W2047361940 @default.
- W2401032354 cites W2048433713 @default.
- W2401032354 cites W2051039198 @default.
- W2401032354 cites W2052542261 @default.
- W2401032354 cites W2055514008 @default.
- W2401032354 cites W2057998085 @default.
- W2401032354 cites W2062786487 @default.
- W2401032354 cites W2063441475 @default.
- W2401032354 cites W2065619933 @default.
- W2401032354 cites W2066599436 @default.
- W2401032354 cites W2072412552 @default.
- W2401032354 cites W2075304537 @default.
- W2401032354 cites W2081912214 @default.
- W2401032354 cites W2082377813 @default.
- W2401032354 cites W2083751216 @default.
- W2401032354 cites W2083870688 @default.
- W2401032354 cites W2087812041 @default.
- W2401032354 cites W2089319449 @default.
- W2401032354 cites W2105388289 @default.
- W2401032354 cites W2108234281 @default.
- W2401032354 cites W2112602336 @default.
- W2401032354 cites W2116126626 @default.
- W2401032354 cites W2119180969 @default.
- W2401032354 cites W2123144544 @default.
- W2401032354 cites W2125744302 @default.
- W2401032354 cites W2125852604 @default.
- W2401032354 cites W2126653569 @default.
- W2401032354 cites W2132261072 @default.
- W2401032354 cites W2135048780 @default.
- W2401032354 cites W2136423167 @default.
- W2401032354 cites W2136446592 @default.
- W2401032354 cites W2136471190 @default.
- W2401032354 cites W2140657325 @default.
- W2401032354 cites W2149716668 @default.
- W2401032354 cites W2149791194 @default.
- W2401032354 cites W2150506261 @default.
- W2401032354 cites W2151318268 @default.
- W2401032354 cites W2155134835 @default.
- W2401032354 cites W2155707112 @default.
- W2401032354 cites W2158619351 @default.
- W2401032354 cites W2160717298 @default.
- W2401032354 cites W2161164257 @default.
- W2401032354 cites W2162490360 @default.
- W2401032354 cites W2162927194 @default.
- W2401032354 cites W2164947706 @default.
- W2401032354 cites W2171777976 @default.
- W2401032354 cites W2233401598 @default.
- W2401032354 cites W2236602350 @default.
- W2401032354 cites W2239528726 @default.
- W2401032354 cites W2296386264 @default.
- W2401032354 cites W2328751003 @default.