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• W2401049530 endingPage "BMI.S38321" @default.
• W2401049530 startingPage "BMI.S38321" @default.
• W2401049530 abstract "The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for susceptibility to essential hypertension (EH).To predict the risk for EH in individuals with C825T genetic polymorphism of G protein β3 gene.The study consisted of 222 normotensive individuals and 216 hypertensive patients. Individuals were genotyped for C825T genetic polymorphism of G protein β3 gene rs5443 by using restriction fragment length polymorphism.Frequencies of C and T alleles were 58.1% and 41.9%, respectively, in the control group compared with 47.7% and 52.3%, respectively, in the hypertensive group. The carriers of rs5443 (T) allele exhibited a significant greater risk for EH compared with the carriers of rs5443 (C) allele (odds ratio = 1.5, 95% confidence interval = 1.2-2.0).T allele is a risk factor for EH in the Egyptian population, which may be used as a prognostic and a therapeutic target of prophylaxis." @default.
• W2401049530 created "2016-06-24" @default.
• W2401049530 creator A5056065144 @default.
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• W2401049530 date "2016-01-01" @default.
• W2401049530 modified "2023-09-27" @default.
• W2401049530 title "Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene" @default.
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• W2401049530 doi "https://doi.org/10.4137/bmi.s38321" @default.
• W2401049530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4871163" @default.
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• W2401049530 hasPublicationYear "2016" @default.
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