Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401111187> ?p ?o ?g. }
- W2401111187 endingPage "1684" @default.
- W2401111187 startingPage "1674" @default.
- W2401111187 abstract "The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests the detrimental roles of cell senescence in the pathogenesis of intervertebral disc degeneration (IDD). Disc cell senescence decreased the number of functional cells in IVD. Moreover, the senescent disc cells were supposed to accelerate the process of IDD via their aberrant paracrine effects by which senescent cells cause the senescence of neighboring cells and enhance the matrix catabolism and inflammation in IVD. Thus, anti-senescence has been proposed as a novel therapeutic target for IDD. However, the development of anti-senescence therapy is based on our understanding of the molecular mechanism of disc cell senescence. In this review, we focused on the molecular mechanism of disc cell senescence, including the causes and various molecular pathways. We found that, during the process of IDD, age-related damages together with degenerative external stimuli activated both p53-p21-Rb and p16-Rb pathways to induce disc cell senescence. Meanwhile, disc cell senescence was regulated by multiple signaling pathways, suggesting the complex regulating network of disc cell senescence. To understand the mechanism of disc cell senescence better contributes to developing the anti-senescence-based therapies for IDD." @default.
- W2401111187 created "2016-06-24" @default.
- W2401111187 creator A5002456827 @default.
- W2401111187 creator A5008263472 @default.
- W2401111187 creator A5013881064 @default.
- W2401111187 creator A5021252332 @default.
- W2401111187 creator A5022802322 @default.
- W2401111187 creator A5082941113 @default.
- W2401111187 date "2016-06-10" @default.
- W2401111187 modified "2023-10-12" @default.
- W2401111187 title "Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways" @default.
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