Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401143451> ?p ?o ?g. }
- W2401143451 abstract "Macrophages accumulate with glioblastoma multiforme (GBM) progression and can be targeted via inhibition of colony-stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models of this cancer. However, whether and how resistance emerges in response to sustained CSF-1R blockade is unknown. We show that although overall survival is significantly prolonged, tumors recur in >50% of mice. Gliomas reestablish sensitivity to CSF-1R inhibition upon transplantation, indicating that resistance is tumor microenvironment-driven. Phosphatidylinositol 3-kinase (PI3K) pathway activity was elevated in recurrent GBM, driven by macrophage-derived insulin-like growth factor-1 (IGF-1) and tumor cell IGF-1 receptor (IGF-1R). Combining IGF-1R or PI3K blockade with CSF-1R inhibition in recurrent tumors significantly prolonged overall survival. Our findings thus reveal a potential therapeutic approach for treating resistance to CSF-1R inhibitors." @default.
- W2401143451 created "2016-06-24" @default.
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- W2401143451 date "2016-05-20" @default.
- W2401143451 modified "2023-10-16" @default.
- W2401143451 title "The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas" @default.
- W2401143451 cites W1506672302 @default.
- W2401143451 cites W1547450219 @default.
- W2401143451 cites W1550700919 @default.
- W2401143451 cites W1797422316 @default.
- W2401143451 cites W1881610795 @default.
- W2401143451 cites W1893588436 @default.
- W2401143451 cites W1946226823 @default.
- W2401143451 cites W1964229968 @default.
- W2401143451 cites W1979240391 @default.
- W2401143451 cites W1980485314 @default.
- W2401143451 cites W1982754708 @default.
- W2401143451 cites W1994914496 @default.
- W2401143451 cites W2002104055 @default.
- W2401143451 cites W2003059883 @default.
- W2401143451 cites W2006366975 @default.
- W2401143451 cites W2007109655 @default.
- W2401143451 cites W2008032601 @default.
- W2401143451 cites W2008134464 @default.
- W2401143451 cites W2008844540 @default.
- W2401143451 cites W2009149174 @default.
- W2401143451 cites W2024460791 @default.
- W2401143451 cites W2026878412 @default.
- W2401143451 cites W2031968704 @default.
- W2401143451 cites W2033278321 @default.
- W2401143451 cites W2035252444 @default.
- W2401143451 cites W2040773741 @default.
- W2401143451 cites W2042619042 @default.
- W2401143451 cites W2043733918 @default.
- W2401143451 cites W2047585900 @default.
- W2401143451 cites W2049085719 @default.
- W2401143451 cites W2050707975 @default.
- W2401143451 cites W2051013988 @default.
- W2401143451 cites W2054472394 @default.
- W2401143451 cites W2061123122 @default.
- W2401143451 cites W2061760261 @default.
- W2401143451 cites W2067443877 @default.
- W2401143451 cites W2070655255 @default.
- W2401143451 cites W2076743146 @default.
- W2401143451 cites W2083423189 @default.
- W2401143451 cites W2089171551 @default.
- W2401143451 cites W2089988801 @default.
- W2401143451 cites W2095463689 @default.
- W2401143451 cites W2096287682 @default.
- W2401143451 cites W2097360283 @default.
- W2401143451 cites W2098487159 @default.
- W2401143451 cites W2104601239 @default.
- W2401143451 cites W2104917184 @default.
- W2401143451 cites W2104968232 @default.
- W2401143451 cites W2108234281 @default.
- W2401143451 cites W2109816625 @default.
- W2401143451 cites W2110617603 @default.
- W2401143451 cites W2115260093 @default.
- W2401143451 cites W2122683221 @default.
- W2401143451 cites W2125493895 @default.
- W2401143451 cites W2125584590 @default.
- W2401143451 cites W2130085763 @default.
- W2401143451 cites W2130410032 @default.
- W2401143451 cites W2134526812 @default.
- W2401143451 cites W2137020659 @default.
- W2401143451 cites W2137526110 @default.
- W2401143451 cites W2139248078 @default.
- W2401143451 cites W2141398932 @default.
- W2401143451 cites W2146839421 @default.
- W2401143451 cites W2149142217 @default.
- W2401143451 cites W2149813574 @default.
- W2401143451 cites W2157561781 @default.
- W2401143451 cites W2159707944 @default.
- W2401143451 cites W2160102037 @default.
- W2401143451 cites W2160382843 @default.
- W2401143451 cites W2162896254 @default.
- W2401143451 cites W2169456326 @default.
- W2401143451 cites W2170273827 @default.
- W2401143451 cites W2211754517 @default.
- W2401143451 cites W2214074259 @default.
- W2401143451 cites W2231000545 @default.
- W2401143451 cites W4230096730 @default.
- W2401143451 cites W4294541781 @default.
- W2401143451 cites W63174853 @default.
- W2401143451 cites W982662479 @default.
- W2401143451 doi "https://doi.org/10.1126/science.aad3018" @default.
- W2401143451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5450629" @default.
- W2401143451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27199435" @default.
- W2401143451 hasPublicationYear "2016" @default.
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