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- W2401168850 endingPage "1152" @default.
- W2401168850 startingPage "1143" @default.
- W2401168850 abstract "This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with a predominance of Alphaproteobacteria. Bacterial groups more relevant for secondary metabolite synthesis have also been revealed. This article summarizes studies reporting the abilities of these communities to produce metabolites with relevant bioactivities. The biotechnological interest of these bacteria for drug discovery is highlighted regarding the production of compounds with therapeutic potential. Special focus is given to the synthesis of the most promising compound, uncialamycin, a potent enediyne isolated from a <i>Streptomyces</i> sp. associated with <i>Cladonia uncialis</i>." @default.
- W2401168850 created "2016-06-24" @default.
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- W2401168850 date "2016-05-24" @default.
- W2401168850 modified "2023-10-18" @default.
- W2401168850 title "Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications" @default.
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- W2401168850 doi "https://doi.org/10.1055/s-0042-105571" @default.
- W2401168850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27220082" @default.
- W2401168850 hasPublicationYear "2016" @default.
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