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• W2401206822 startingPage "10372" @default.
• W2401206822 abstract "Nitrate salts are widely used as food additives and nitrogenous fertilizers and are present as contaminants in drinking water supplies. The effect of different concentrations (1-15 mM) of sodium nitrate (NaNO3) on human erythrocytes was studied under in vitro conditions. Treatment of erythrocytes with NaNO3 resulted in increases in methemoglobin levels, lipid peroxidation, and protein oxidation and a decrease in glutathione content. There were changes in the activities of all major antioxidant defense enzymes, and the pathways of glucose metabolism were also affected. Increased generation of reactive oxygen species (ROS) took place while the antioxidant power was impaired. The osmotic fragility of cells was increased, and membrane-bound enzymes were greatly inhibited. All changes were statistically significant at a probability level of P < 0.05 at all concentrations of NaNO3 except the lowest (1 mM). Thus, NaNO3 generates ROS that cause significant damage to human erythrocytes and interfere in normal cellular pathways." @default.
• W2401206822 created "2016-06-24" @default.
• W2401206822 creator A5005163376 @default.
• W2401206822 creator A5023338166 @default.
• W2401206822 date "2015-11-30" @default.
• W2401206822 modified "2023-10-05" @default.
• W2401206822 title "Sodium Nitrate Induces Reactive Oxygen Species That Lower the Antioxidant Power, Damage the Membrane, and Alter Pathways of Glucose Metabolism in Human Erythrocytes" @default.
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• W2401206822 doi "https://doi.org/10.1021/acs.jafc.5b04898" @default.
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