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• W2401243443 abstract "Ultrasound and microbubbles-mediated drug delivery has become a promising strategy to promote drug delivery and its therapeutic efficacy. The aim of this research was to assess the effects of microbubbles (MBs)-combined low-intensity pulsed ultrasound (LPUS) on the delivery and cytotoxicity of curcumin (Cur) to human breast cancer MDA-MB-231 cells. Under the experimental condition, MBs raised the level of acoustic cavitation and enhanced plasma membrane permeability; and cellular uptake of Cur was notably improved by LPUS-MBs treatment, aggravating Cur-induced MDA-MB-231 cells death. The combined treatment markedly caused more obvious changes of cell morphology, F-actin cytoskeleton damage and cell migration inhibition. Our results demonstrated that combination of MBs and LPUS may be an efficient strategy for improving anti-tumor effect of Cur, suggesting a potential effective method for antineoplastic therapy." @default.
• W2401243443 created "2016-06-24" @default.
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• W2401243443 date "2016-11-01" @default.
• W2401243443 modified "2023-10-13" @default.
• W2401243443 title "Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells" @default.
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• W2401243443 doi "https://doi.org/10.1016/j.ultsonch.2016.04.012" @default.
• W2401243443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27245953" @default.
• W2401243443 hasPublicationYear "2016" @default.
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