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- W2401289504 endingPage "968" @default.
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- W2401289504 abstract "Background: Nutritional interventions are promising treatment adjuncts in the management of concussion. Vitamin D (VDH) supplementation has demonstrated neuroprotective properties in multiple models of acquired brain injury.Objective: Review the neuroprotective role of VDH supplementation following traumatic brain injury (TBI).Methods: A Medline search was conducted to review manuscripts investigating the influence of VDH status or supplementation on TBI outcomes.Results: The search identified 165 studies, of which five were included. Four manuscripts studied a rodent model of TBI, while one studied a clinical sample. Vitamin D monotherapy independently reduced inflammation and neuronal injury following TBI, with a more robust effect observed in combination with progesterone (PROG). One study demonstrated VDH deficiency exacerbates post-TBI inflammatory response. One study in a clinical sample found combination therapy superior to PROG alone or placebo in improving outcomes after severe TBI. One study observed a more robust response to low-dose VDH compared to high-dose VDH when given in combination with PROG.Conclusion: A protective role for VDH and a vitamin D sufficient status was identified for numerous outcomes following TBI. However, VDH supplementation cannot be recommended at this time to improve outcomes following TBI." @default.
- W2401289504 created "2016-06-24" @default.
- W2401289504 creator A5015849619 @default.
- W2401289504 creator A5080548305 @default.
- W2401289504 date "2016-05-16" @default.
- W2401289504 modified "2023-10-18" @default.
- W2401289504 title "A review of the neuroprotective role of vitamin D in traumatic brain injury with implications for supplementation post-concussion" @default.
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- W2401289504 doi "https://doi.org/10.3109/02699052.2016.1147081" @default.
- W2401289504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27185224" @default.
- W2401289504 hasPublicationYear "2016" @default.