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- W2401333506 abstract "The ability of glucocorticoids (GCs) to kill lymphoid cells via a process called apoptosis has led to their inclusion in essentially all chemotherapy protocols for lymphoid malignancies. Since GC receptor(GR) is a ligand-dependent transcription factor, there should be genes mediating apoptosis among the ones whose expression is induced by GC. This review summarizes recent advances related to the molecular basis of GC-induced apoptosis, focusing on microarray analysis. Various groups of genes have been identified as candidate target genes of GR including the ones encoding Bcl-2 family proteins and calcineurin inhibitors. Although further investigation is required to determine the genes causally involved in GC-induced apoptosis, the studies described here will hopefully lead to more efficient treatments of lymphoid malignancies." @default.
- W2401333506 created "2016-06-24" @default.
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- W2401333506 date "2008-01-01" @default.
- W2401333506 modified "2023-09-24" @default.
- W2401333506 title "[Anti-tumor activities of steroids--lessons from microarray analysis]." @default.
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