Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401335918> ?p ?o ?g. }
- W2401335918 endingPage "1732" @default.
- W2401335918 startingPage "1727" @default.
- W2401335918 abstract "<h3>BACKGROUND AND PURPOSE:</h3> Children with sickle cell disease have low hematocrit and elevated CBF, the latter of which can be assessed with arterial spin-labeling MR imaging. Quantitative CBF values are obtained by using an estimation of the longitudinal relaxation time of blood (T1<sub>blood</sub>). Because T1<sub>blood</sub> depends on hematocrit in healthy individuals, we investigated the importance of measuring T1<sub>blood</sub> in vivo with MR imaging versus calculating it from hematocrit or assuming an adult fixed value recommended by the literature, hypothesizing that measured T1<sub>blood</sub> would be the most suited for CBF quantification in children with sickle cell disease. <h3>MATERIALS AND METHODS:</h3> Four approaches for T1<sub>blood</sub> estimation were investigated in 39 patients with sickle cell disease and subsequently used in the CBF quantification from arterial spin-labeling MR imaging. First, we used 1650 ms as recommended by the literature (T1<sub>blood</sub>-fixed); second, T1<sub>blood</sub> calculated from hematocrit measured in patients (T1<sub>blood</sub>-hematocrit); third, T1<sub>blood</sub> measured in vivo with a Look-Locker MR imaging sequence (T1<sub>blood</sub>-measured); and finally, a mean value from T1<sub>blood</sub> measured in this study in children with sickle cell disease (T1<sub>blood</sub>–sickle cell disease). Quantitative flow measurements acquired with phase-contrast MR imaging served as reference values for CBF. <h3>RESULTS:</h3> T1<sub>blood</sub>-measured (1818 ± 107 ms) was higher than the literature recommended value of 1650 ms, was significantly lower than T1<sub>blood</sub>-hematocrit (2058 ± 123 ms, <i>P</i> < .001), and, most interesting, did not correlate with hematocrit measurements. Use of either T1<sub>blood</sub>-measured or T1<sub>blood</sub>–sickle cell disease provided the best agreement on CBF between arterial-spin labeling and phase-contrast MR imaging reference values. <h3>CONCLUSIONS:</h3> This work advocates the use of patient-specific measured T1<sub>blood</sub> or a standardized value (1818 ms) in the quantification of CBF from arterial spin-labeling in children with SCD." @default.
- W2401335918 created "2016-06-24" @default.
- W2401335918 creator A5010400745 @default.
- W2401335918 creator A5024309954 @default.
- W2401335918 creator A5024827532 @default.
- W2401335918 creator A5034495408 @default.
- W2401335918 creator A5040266732 @default.
- W2401335918 creator A5043026808 @default.
- W2401335918 creator A5064910180 @default.
- W2401335918 creator A5070504139 @default.
- W2401335918 creator A5079735182 @default.
- W2401335918 creator A5079993239 @default.
- W2401335918 creator A5081673460 @default.
- W2401335918 date "2016-05-26" @default.
- W2401335918 modified "2023-10-16" @default.
- W2401335918 title "In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI" @default.
- W2401335918 cites W1513156534 @default.
- W2401335918 cites W1582676028 @default.
- W2401335918 cites W1914061050 @default.
- W2401335918 cites W1966362593 @default.
- W2401335918 cites W1967104918 @default.
- W2401335918 cites W1976099054 @default.
- W2401335918 cites W1977896272 @default.
- W2401335918 cites W1981314274 @default.
- W2401335918 cites W1981964569 @default.
- W2401335918 cites W1987888423 @default.
- W2401335918 cites W1989704288 @default.
- W2401335918 cites W1992323755 @default.
- W2401335918 cites W2012602334 @default.
- W2401335918 cites W2037543554 @default.
- W2401335918 cites W2039888550 @default.
- W2401335918 cites W2040032797 @default.
- W2401335918 cites W2048310364 @default.
- W2401335918 cites W2057320092 @default.
- W2401335918 cites W2059072071 @default.
- W2401335918 cites W2060027731 @default.
- W2401335918 cites W2074274705 @default.
- W2401335918 cites W2074846179 @default.
- W2401335918 cites W2081036197 @default.
- W2401335918 cites W2083397096 @default.
- W2401335918 cites W2093068635 @default.
- W2401335918 cites W2099068027 @default.
- W2401335918 cites W2100082339 @default.
- W2401335918 cites W2102253388 @default.
- W2401335918 cites W2104773315 @default.
- W2401335918 cites W2105827450 @default.
- W2401335918 cites W2112684181 @default.
- W2401335918 cites W2116641010 @default.
- W2401335918 cites W2116991535 @default.
- W2401335918 cites W2126322809 @default.
- W2401335918 cites W2145254122 @default.
- W2401335918 cites W2153405814 @default.
- W2401335918 cites W2163565535 @default.
- W2401335918 cites W2264928617 @default.
- W2401335918 cites W3141197395 @default.
- W2401335918 doi "https://doi.org/10.3174/ajnr.a4793" @default.
- W2401335918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7984682" @default.
- W2401335918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27231223" @default.
- W2401335918 hasPublicationYear "2016" @default.
- W2401335918 type Work @default.
- W2401335918 sameAs 2401335918 @default.
- W2401335918 citedByCount "36" @default.
- W2401335918 countsByYear W24013359182017 @default.
- W2401335918 countsByYear W24013359182018 @default.
- W2401335918 countsByYear W24013359182019 @default.
- W2401335918 countsByYear W24013359182020 @default.
- W2401335918 countsByYear W24013359182021 @default.
- W2401335918 countsByYear W24013359182022 @default.
- W2401335918 countsByYear W24013359182023 @default.
- W2401335918 crossrefType "journal-article" @default.
- W2401335918 hasAuthorship W2401335918A5010400745 @default.
- W2401335918 hasAuthorship W2401335918A5024309954 @default.
- W2401335918 hasAuthorship W2401335918A5024827532 @default.
- W2401335918 hasAuthorship W2401335918A5034495408 @default.
- W2401335918 hasAuthorship W2401335918A5040266732 @default.
- W2401335918 hasAuthorship W2401335918A5043026808 @default.
- W2401335918 hasAuthorship W2401335918A5064910180 @default.
- W2401335918 hasAuthorship W2401335918A5070504139 @default.
- W2401335918 hasAuthorship W2401335918A5079735182 @default.
- W2401335918 hasAuthorship W2401335918A5079993239 @default.
- W2401335918 hasAuthorship W2401335918A5081673460 @default.
- W2401335918 hasBestOaLocation W24013359181 @default.
- W2401335918 hasConcept C121332964 @default.
- W2401335918 hasConcept C126322002 @default.
- W2401335918 hasConcept C126838900 @default.
- W2401335918 hasConcept C142724271 @default.
- W2401335918 hasConcept C143409427 @default.
- W2401335918 hasConcept C150903083 @default.
- W2401335918 hasConcept C157767197 @default.
- W2401335918 hasConcept C158846371 @default.
- W2401335918 hasConcept C164705383 @default.
- W2401335918 hasConcept C178853913 @default.
- W2401335918 hasConcept C207001950 @default.
- W2401335918 hasConcept C2776557347 @default.
- W2401335918 hasConcept C2778620579 @default.
- W2401335918 hasConcept C2779134260 @default.
- W2401335918 hasConcept C2780959883 @default.
- W2401335918 hasConcept C2989005 @default.