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- W2401384927 abstract "For both Rabbit Haemorrhagic Disease and Myxomatosis viruses, vaccination is made in order to increase the specific humoral and/or cellular immune response of the animals and protect against disease. The aim of our work is to detect the humoral immune response, using competition ELISAs (cELISA) as diagnostic tests, in breeders and fattening rabbits vaccinated with different types of vaccines and by variable route of administrations against myxomatosis and RHDV. Difference in serological response were analysed by mixed model on a logaritmic transformation of titres. In all the vaccinated groups a specific seroconversion was observed. As expected the highest average values were detected among multiparous breeders, which had been previously vaccinated several times. For breeders, the linear mixed models for serological responses show a very important interaction effects between “Day of Sampling” and “Kind of Vaccination” group. The most relevant difference in fattening rabbits vaccinated for the first time against myxomatosis was, as expected, the absolute lower levels of antibodies detected. The linear mixed model for Myxomatosis serological response in fattening rabbits show a significant interaction between “Day of Sampling” and “Kind of Vaccination”. Moreover, by using RHDV serological methods (cELISA and anti-isotype IgG-IgA-IgM ELISAs) all the rabbits tested at 28 days of age showed passive antibodies of maternal origin against RHD. Therefore we cannot exclude that the presence of antibodies at different titres at the moment of first vaccination could have conditioned the effect of immunization. The results obtained in this study demonstrate that serological methods could be a valid aid in monitoring the efficacy of vacc ination for both Myxomatosis and RHD. Using methods having a high level of specificity, it was possible to detect seroconversion in groups of rabbits vaccinated with different type of vaccines. Indeed, serology and particularly the combination of RHDV anti-isotypes ELISAs could help to improve the quality of vaccination by determining the more convenient moment to administrate the first vaccination in relation to the disappearance of maternal antibodies." @default.
- W2401384927 created "2016-06-24" @default.
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- W2401384927 date "2004-01-01" @default.
- W2401384927 modified "2023-10-17" @default.
- W2401384927 title "SEROLOGICAL EVALUATION OF THE IMMUNITY INDUCED IN COMMERCIAL RABBITS BY VACCINATION FOR MYXOMATOSIS AND RHD" @default.
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