Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401450306> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2401450306 endingPage "318" @default.
- W2401450306 startingPage "313" @default.
- W2401450306 abstract "OBJECTIVES: Taking into account the hypothesis that Alzheimer's disease (AD) might be a systemic disease that affects several tissues in the body, the aim of this study was to try to detect the expression of tau-protein in human peripheral blood lymphocytes (PBL) in patients with AD. MATERIAL AND METHODS: Blood samples were obtained from patients with AD (n=16, age 67-98) and from volunteers without psychoneurological pathology (n=10, age 65-78). PBL were isolated on Ficoll-Paque gradient centrifugation. For cell fixation and permeabilization we used a fixative solution (4% formaldehyde and 0.1% glutaraldehyde) and 0.03% Triton X-100. Immunocytochemical detection of tau-protein was carried out by biotin-streptavidin complex method with tau monoclonal antibody (1:100, clone TAU-2, ICN) and universal immunostaining kit IMMU-MARK (ICN). RESULTS: The expression of tau-protein was shown in PBL in absolute majority of AD patients studied. Only in two healthy volunteers a single lymphocyte from many cells (i.e. a smear) demonstrated a very weak-positive immunostaining to tau-protein CONCLUSION: This first demonstration of clear difference in localization of tau-protein in blood lymphocytes between healthy and sick people testifies to the fact that tau-protein could be considered as a promising marker and blood lymphocytes as a suitable sample for life-time diagnosis of AD." @default.
- W2401450306 created "2016-06-24" @default.
- W2401450306 creator A5003057712 @default.
- W2401450306 creator A5005331259 @default.
- W2401450306 creator A5012307226 @default.
- W2401450306 creator A5013421389 @default.
- W2401450306 creator A5020651173 @default.
- W2401450306 creator A5027443562 @default.
- W2401450306 creator A5039115502 @default.
- W2401450306 creator A5039192618 @default.
- W2401450306 creator A5045353505 @default.
- W2401450306 creator A5052088401 @default.
- W2401450306 creator A5052788071 @default.
- W2401450306 creator A5062635269 @default.
- W2401450306 creator A5062719301 @default.
- W2401450306 creator A5070646074 @default.
- W2401450306 date "2000-01-01" @default.
- W2401450306 modified "2023-10-06" @default.
- W2401450306 title "Tau-protein expression in human blood lymphocytes: a promising marker and suitable sample for life-time diagnosis of Alzheimer's disease." @default.
- W2401450306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11455366" @default.
- W2401450306 hasPublicationYear "2000" @default.
- W2401450306 type Work @default.
- W2401450306 sameAs 2401450306 @default.
- W2401450306 citedByCount "5" @default.
- W2401450306 countsByYear W24014503062023 @default.
- W2401450306 crossrefType "journal-article" @default.
- W2401450306 hasAuthorship W2401450306A5003057712 @default.
- W2401450306 hasAuthorship W2401450306A5005331259 @default.
- W2401450306 hasAuthorship W2401450306A5012307226 @default.
- W2401450306 hasAuthorship W2401450306A5013421389 @default.
- W2401450306 hasAuthorship W2401450306A5020651173 @default.
- W2401450306 hasAuthorship W2401450306A5027443562 @default.
- W2401450306 hasAuthorship W2401450306A5039115502 @default.
- W2401450306 hasAuthorship W2401450306A5039192618 @default.
- W2401450306 hasAuthorship W2401450306A5045353505 @default.
- W2401450306 hasAuthorship W2401450306A5052088401 @default.
- W2401450306 hasAuthorship W2401450306A5052788071 @default.
- W2401450306 hasAuthorship W2401450306A5062635269 @default.
- W2401450306 hasAuthorship W2401450306A5062719301 @default.
- W2401450306 hasAuthorship W2401450306A5070646074 @default.
- W2401450306 hasConcept C142724271 @default.
- W2401450306 hasConcept C153911025 @default.
- W2401450306 hasConcept C159654299 @default.
- W2401450306 hasConcept C203014093 @default.
- W2401450306 hasConcept C204232928 @default.
- W2401450306 hasConcept C2776190903 @default.
- W2401450306 hasConcept C2777761686 @default.
- W2401450306 hasConcept C2777910003 @default.
- W2401450306 hasConcept C2778204606 @default.
- W2401450306 hasConcept C2779134260 @default.
- W2401450306 hasConcept C2780848204 @default.
- W2401450306 hasConcept C4224716 @default.
- W2401450306 hasConcept C502032728 @default.
- W2401450306 hasConcept C55493867 @default.
- W2401450306 hasConcept C71924100 @default.
- W2401450306 hasConcept C74864618 @default.
- W2401450306 hasConcept C86803240 @default.
- W2401450306 hasConceptScore W2401450306C142724271 @default.
- W2401450306 hasConceptScore W2401450306C153911025 @default.
- W2401450306 hasConceptScore W2401450306C159654299 @default.
- W2401450306 hasConceptScore W2401450306C203014093 @default.
- W2401450306 hasConceptScore W2401450306C204232928 @default.
- W2401450306 hasConceptScore W2401450306C2776190903 @default.
- W2401450306 hasConceptScore W2401450306C2777761686 @default.
- W2401450306 hasConceptScore W2401450306C2777910003 @default.
- W2401450306 hasConceptScore W2401450306C2778204606 @default.
- W2401450306 hasConceptScore W2401450306C2779134260 @default.
- W2401450306 hasConceptScore W2401450306C2780848204 @default.
- W2401450306 hasConceptScore W2401450306C4224716 @default.
- W2401450306 hasConceptScore W2401450306C502032728 @default.
- W2401450306 hasConceptScore W2401450306C55493867 @default.
- W2401450306 hasConceptScore W2401450306C71924100 @default.
- W2401450306 hasConceptScore W2401450306C74864618 @default.
- W2401450306 hasConceptScore W2401450306C86803240 @default.
- W2401450306 hasIssue "4" @default.
- W2401450306 hasLocation W24014503061 @default.
- W2401450306 hasOpenAccess W2401450306 @default.
- W2401450306 hasPrimaryLocation W24014503061 @default.
- W2401450306 hasRelatedWork W1976161893 @default.
- W2401450306 hasRelatedWork W1981611179 @default.
- W2401450306 hasRelatedWork W1987657304 @default.
- W2401450306 hasRelatedWork W2037172643 @default.
- W2401450306 hasRelatedWork W2054026083 @default.
- W2401450306 hasRelatedWork W2088430156 @default.
- W2401450306 hasRelatedWork W2401450306 @default.
- W2401450306 hasRelatedWork W2464068520 @default.
- W2401450306 hasRelatedWork W3155608666 @default.
- W2401450306 hasRelatedWork W4210924846 @default.
- W2401450306 hasVolume "21" @default.
- W2401450306 isParatext "false" @default.
- W2401450306 isRetracted "false" @default.
- W2401450306 magId "2401450306" @default.
- W2401450306 workType "article" @default.