Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401452542> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2401452542 endingPage "8" @default.
- W2401452542 startingPage "4395" @default.
- W2401452542 abstract "Increased or de novo expression of certain CD44 variant isofoms as well as abnormal processing of pre-mRNA of the CD44 gene have been found in different malignant human tumors. Retention of the non-coding intron 9 sequence in CD44 mRNA especially, appears to be a discriminating aberrant splicing pattern in several cancer tissues and cells. We examined the expression of the CD44 intron 9 sequence in the mRNA of 45 permanent ovarian cancer cell lines and in normal ovarian tissue. Abnormal retention of intron 9 was found in 19 (60%) cell lines expressing CD44 std. Normal ovarian tissue as well as all ovarian cancer cells without CD44 s t d expression were found to be negative for intron 9 retention. Our results indicate that besides newly acquired expression of certain CD44 isoforms abnormal retention of the non-coding intron 9 sequence in CD44 gene transcripts is also a common and maybe crucial event in the tumorigenesis of ovarian cancer. Since intron 9 is not retained in normal ovarian tissue this aberration might serve as a marker for human adenocarcinoma of the ovary." @default.
- W2401452542 created "2016-06-24" @default.
- W2401452542 creator A5000590622 @default.
- W2401452542 creator A5008644034 @default.
- W2401452542 creator A5017517167 @default.
- W2401452542 creator A5044504864 @default.
- W2401452542 creator A5052081262 @default.
- W2401452542 creator A5075265190 @default.
- W2401452542 date "1998-03-12" @default.
- W2401452542 modified "2023-10-17" @default.
- W2401452542 title "Intron 9 retention in gene transcripts suggests involvement of CD44 in the tumorigenesis of ovarian cancer." @default.
- W2401452542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9494539" @default.
- W2401452542 hasPublicationYear "1998" @default.
- W2401452542 type Work @default.
- W2401452542 sameAs 2401452542 @default.
- W2401452542 citedByCount "3" @default.
- W2401452542 countsByYear W24014525422014 @default.
- W2401452542 crossrefType "journal-article" @default.
- W2401452542 hasAuthorship W2401452542A5000590622 @default.
- W2401452542 hasAuthorship W2401452542A5008644034 @default.
- W2401452542 hasAuthorship W2401452542A5017517167 @default.
- W2401452542 hasAuthorship W2401452542A5044504864 @default.
- W2401452542 hasAuthorship W2401452542A5052081262 @default.
- W2401452542 hasAuthorship W2401452542A5075265190 @default.
- W2401452542 hasConcept C104317684 @default.
- W2401452542 hasConcept C121608353 @default.
- W2401452542 hasConcept C1491633281 @default.
- W2401452542 hasConcept C194583182 @default.
- W2401452542 hasConcept C2780427987 @default.
- W2401452542 hasConcept C2780932548 @default.
- W2401452542 hasConcept C36823959 @default.
- W2401452542 hasConcept C502942594 @default.
- W2401452542 hasConcept C54355233 @default.
- W2401452542 hasConcept C54458228 @default.
- W2401452542 hasConcept C555283112 @default.
- W2401452542 hasConcept C67705224 @default.
- W2401452542 hasConcept C86803240 @default.
- W2401452542 hasConcept C91779695 @default.
- W2401452542 hasConcept C94671646 @default.
- W2401452542 hasConceptScore W2401452542C104317684 @default.
- W2401452542 hasConceptScore W2401452542C121608353 @default.
- W2401452542 hasConceptScore W2401452542C1491633281 @default.
- W2401452542 hasConceptScore W2401452542C194583182 @default.
- W2401452542 hasConceptScore W2401452542C2780427987 @default.
- W2401452542 hasConceptScore W2401452542C2780932548 @default.
- W2401452542 hasConceptScore W2401452542C36823959 @default.
- W2401452542 hasConceptScore W2401452542C502942594 @default.
- W2401452542 hasConceptScore W2401452542C54355233 @default.
- W2401452542 hasConceptScore W2401452542C54458228 @default.
- W2401452542 hasConceptScore W2401452542C555283112 @default.
- W2401452542 hasConceptScore W2401452542C67705224 @default.
- W2401452542 hasConceptScore W2401452542C86803240 @default.
- W2401452542 hasConceptScore W2401452542C91779695 @default.
- W2401452542 hasConceptScore W2401452542C94671646 @default.
- W2401452542 hasIssue "6D" @default.
- W2401452542 hasLocation W24014525421 @default.
- W2401452542 hasOpenAccess W2401452542 @default.
- W2401452542 hasPrimaryLocation W24014525421 @default.
- W2401452542 hasRelatedWork W1977599835 @default.
- W2401452542 hasRelatedWork W2018387988 @default.
- W2401452542 hasRelatedWork W2020400816 @default.
- W2401452542 hasRelatedWork W2097331814 @default.
- W2401452542 hasRelatedWork W2113067903 @default.
- W2401452542 hasRelatedWork W2185405608 @default.
- W2401452542 hasRelatedWork W2227731780 @default.
- W2401452542 hasRelatedWork W2315599716 @default.
- W2401452542 hasRelatedWork W2401452542 @default.
- W2401452542 hasRelatedWork W2512791253 @default.
- W2401452542 hasVolume "17" @default.
- W2401452542 isParatext "false" @default.
- W2401452542 isRetracted "false" @default.
- W2401452542 magId "2401452542" @default.
- W2401452542 workType "article" @default.