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- W240145257 abstract "Objective:To determine the methylation status of E-cadherin(CDH1) and PAX1 gene,the member of paired box family,in cervical carcinoma tissues,human papillomavirus(HPV)-infected normal cervical tissues,cervicitis tissues,cervical intraepithelial neoplasia(CIN) Ⅰ tissues,and CIN Ⅱ-Ⅲ tissues,and assess whether changes in methylation status can be used as a mole-cular marker in clinic diagnosis.Methods:Methylation status of CDH1 and PAX1 gene was detected using methylation-specific PCR(MSP) in HPV-infected normal cervical tissues(n=15),cervicitis tissues(n=15),CINⅠ tissues(n=15),CINⅡ-Ⅲ tissues(n=15),and cervical carcinoma(n=40) tissues.Results:(1) CDH1 methylation was undetected in HPV-infected normal cervical tissues,cervicitis and CINⅠspecimens,while it was frequently observed in two CINⅡ-Ⅲ specimens and nine cervical carcinoma specimens(13.3% and 22.5%,respectively).The difference was significant compared with HPV-infected normal cervical tissues(P0.05).(2) PAX1 methylation was not observed in HPV-infected normal cervical tissues and cervicitis specimens.The positivity of methylation was 13.3%,46.7%,and 87.5% in CINⅠ,CINⅡ-Ⅲ,and cervical carcinoma specimens,respectively.The difference was significant between CINⅠand CINⅡ-Ⅲ specimens and cervical carcinoma specimens(P0.05).(3) Hypermethylation was more frequent in CIN Ⅱ-Ⅲ than in CIN Ⅰ specimens(60.0% vs 13.5%,P0.05) as well as in cervical carcinoma than in CIN Ⅱ-Ⅲ specimens(97.5% vs 60.0%,P0.05).Conclusion:Methylation of CDH1 and PAX1 gene,especially PAX1 gene,may have a potential value for diagnosis of cervical carcinoma in clinic." @default.
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- W240145257 date "2009-01-01" @default.
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- W240145257 title "Study on the methylation status of CDH1 and PAX1 genes in human cervical carcinoma tissues." @default.
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