Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401473670> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2401473670 endingPage "gfv438" @default.
- W2401473670 startingPage "gfv438" @default.
- W2401473670 abstract "Background. Calcific uraemic arteriolopathy (CUA, calciphylaxis) is a rare disease predominantly in dialysis patients and associated with high mortality. Painful skin ulcerations and calcification of cutaneous arterioles characterize calciphylaxis. Methods. We established an observational, Internet-based registry allowing online notification for all German CUA cases. The registry recorded data about patient characteristics, biochemistry and therapies. Blood samples were stored in a central biobank. Results. Between 2006 and 2015, 253 CUA patients were recorded: median age 70 [interquartile range (IQR) 61–76] years, 60% females and 86% (n = 207) dialysis patients, translating into an estimated annual incidence rate of 0.04% in German dialysis patients. Fifty-two per cent received vitamin K antagonists (VKAs) prior to CUA. Skin lesions were localized in 71% on the legs or gluteal region. In dialysis CUA patients median total serum calcium was 2.20 (IQR 2.06–2.37) mmol/L, phosphorus 1.67 (IQR 1.35–2.03) mmol/L, intact parathyroid hormone 147 (IQR 72–276) pg/mL and fetuin-A 0.21 (IQR 0.16–0.26) g/L (normal range 0.35–0.95). Median sclerostin, osteoprotegerin, TRAP5b, bone-specific alkaline phosphatase and c-terminal FGF23 levels were all elevated. The most frequently recorded therapeutic procedures in dialysis CUA patients were as follows: wound debridement (29% of cases), stopping VKA (25%), lowering calcium supply (24%), sodium thiosulphate (22%), application of vitamin K (18%), increase of dialysis duration/frequency (17%) and stoping active vitamin D (16%). Conclusions. Approximately 50% of CUA patients used VKA. Our data suggest that uncontrolled hyperparathyroidism is not the key determinant of calciphylaxis. Therapeutic strategies were heterogeneous. The experience of the German registry will help substantially to initiate a large-scale multinational CUA registry." @default.
- W2401473670 created "2016-06-24" @default.
- W2401473670 creator A5001027249 @default.
- W2401473670 creator A5010095061 @default.
- W2401473670 creator A5027966081 @default.
- W2401473670 creator A5028674815 @default.
- W2401473670 creator A5031322240 @default.
- W2401473670 creator A5031427923 @default.
- W2401473670 creator A5038575110 @default.
- W2401473670 creator A5046643853 @default.
- W2401473670 creator A5055189121 @default.
- W2401473670 creator A5087619854 @default.
- W2401473670 date "2016-01-29" @default.
- W2401473670 modified "2023-10-17" @default.
- W2401473670 title "Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry" @default.
- W2401473670 cites W1528653933 @default.
- W2401473670 cites W1800067814 @default.
- W2401473670 cites W1982988663 @default.
- W2401473670 cites W2022549656 @default.
- W2401473670 cites W2037099425 @default.
- W2401473670 cites W2041321546 @default.
- W2401473670 cites W2043723189 @default.
- W2401473670 cites W2084790107 @default.
- W2401473670 cites W2095835825 @default.
- W2401473670 cites W2103334043 @default.
- W2401473670 cites W2106640938 @default.
- W2401473670 cites W2118943059 @default.
- W2401473670 cites W2144976593 @default.
- W2401473670 cites W2158440171 @default.
- W2401473670 cites W2298095883 @default.
- W2401473670 doi "https://doi.org/10.1093/ndt/gfv438" @default.
- W2401473670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26908770" @default.
- W2401473670 hasPublicationYear "2016" @default.
- W2401473670 type Work @default.
- W2401473670 sameAs 2401473670 @default.
- W2401473670 citedByCount "62" @default.
- W2401473670 countsByYear W24014736702016 @default.
- W2401473670 countsByYear W24014736702017 @default.
- W2401473670 countsByYear W24014736702018 @default.
- W2401473670 countsByYear W24014736702019 @default.
- W2401473670 countsByYear W24014736702020 @default.
- W2401473670 countsByYear W24014736702021 @default.
- W2401473670 countsByYear W24014736702022 @default.
- W2401473670 countsByYear W24014736702023 @default.
- W2401473670 crossrefType "journal-article" @default.
- W2401473670 hasAuthorship W2401473670A5001027249 @default.
- W2401473670 hasAuthorship W2401473670A5010095061 @default.
- W2401473670 hasAuthorship W2401473670A5027966081 @default.
- W2401473670 hasAuthorship W2401473670A5028674815 @default.
- W2401473670 hasAuthorship W2401473670A5031322240 @default.
- W2401473670 hasAuthorship W2401473670A5031427923 @default.
- W2401473670 hasAuthorship W2401473670A5038575110 @default.
- W2401473670 hasAuthorship W2401473670A5046643853 @default.
- W2401473670 hasAuthorship W2401473670A5055189121 @default.
- W2401473670 hasAuthorship W2401473670A5087619854 @default.
- W2401473670 hasBestOaLocation W24014736701 @default.
- W2401473670 hasConcept C119060515 @default.
- W2401473670 hasConcept C124490489 @default.
- W2401473670 hasConcept C126322002 @default.
- W2401473670 hasConcept C141071460 @default.
- W2401473670 hasConcept C2776954043 @default.
- W2401473670 hasConcept C2778063415 @default.
- W2401473670 hasConcept C2779978075 @default.
- W2401473670 hasConcept C2780309369 @default.
- W2401473670 hasConcept C54847362 @default.
- W2401473670 hasConcept C71924100 @default.
- W2401473670 hasConcept C90924648 @default.
- W2401473670 hasConceptScore W2401473670C119060515 @default.
- W2401473670 hasConceptScore W2401473670C124490489 @default.
- W2401473670 hasConceptScore W2401473670C126322002 @default.
- W2401473670 hasConceptScore W2401473670C141071460 @default.
- W2401473670 hasConceptScore W2401473670C2776954043 @default.
- W2401473670 hasConceptScore W2401473670C2778063415 @default.
- W2401473670 hasConceptScore W2401473670C2779978075 @default.
- W2401473670 hasConceptScore W2401473670C2780309369 @default.
- W2401473670 hasConceptScore W2401473670C54847362 @default.
- W2401473670 hasConceptScore W2401473670C71924100 @default.
- W2401473670 hasConceptScore W2401473670C90924648 @default.
- W2401473670 hasLocation W24014736701 @default.
- W2401473670 hasLocation W24014736702 @default.
- W2401473670 hasOpenAccess W2401473670 @default.
- W2401473670 hasPrimaryLocation W24014736701 @default.
- W2401473670 hasRelatedWork W1563120570 @default.
- W2401473670 hasRelatedWork W2089217516 @default.
- W2401473670 hasRelatedWork W2141043112 @default.
- W2401473670 hasRelatedWork W2417054819 @default.
- W2401473670 hasRelatedWork W2574098881 @default.
- W2401473670 hasRelatedWork W2791361296 @default.
- W2401473670 hasRelatedWork W4210421255 @default.
- W2401473670 hasRelatedWork W4224254679 @default.
- W2401473670 hasRelatedWork W4230108413 @default.
- W2401473670 hasRelatedWork W4387137115 @default.
- W2401473670 isParatext "false" @default.
- W2401473670 isRetracted "false" @default.
- W2401473670 magId "2401473670" @default.
- W2401473670 workType "article" @default.