Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401476471> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2401476471 endingPage "9" @default.
- W2401476471 startingPage "1564" @default.
- W2401476471 abstract "To investigate the regulatory effects of RhoGTPase on the transition of liver sinusoidal endothelial cells and the potential mechanism thereof on the sinusoidal capillarization in schistosomal hepatic fibrosis.Eight-eight mice underwent abdominal infection of schistosomal cercaria so as to establish liver fibrosis models. 13 weeks later the mice were divided into 5 groups: Group A (normal control group, n = 10), Group B (group of schistosomiasis, n = 24), Group C (anti-schistosoma control group, treated with biltricide), Group D (group of schistosomiasis + hydroxyfasudil, treated with hydroxyfasudil since the week 14, n = 18), and Group E (biltricide + hydroxyfasudil, treated with biltricide since week 13 and added with hydroxyfasudil since week 14, n = 18). The mice in Group A and 6 mice of Group B were killed in week 13, and 6 mice of Groups B, C, D, and E were killed in weeks 16, 19, and 21 each. The livers were taken out to undergo electron microcopy. Immunohistochemistry was used to detect the expression of p-moesin, connective tissue growth factor (CTGF), RhoA, collagen IV (Col IV), and laminin (LN) protein expressions were assessed by Western blotting, and RT-PCR was used to detect the mRNA expression of CTGF, RhoA, and ROCK II.Compared with Group A, the mRNA levels of RhoA, ROCK II, and CTGF were significantly increased (all P < 0.05) and the protein expression levels of p-moesin, CTGF, RhoA, Col IV, and LN were significantly increased (all P < 0.05) in Group B. After intervention with biltricide and/or hydroxyfasudil, the CTGF mRNA expression was significantly decreased (P < 0.05) in Group E in week 16 and the protein expression levels of CTGF, Col IV, and LN were decreased (all P < 0.05) compared with other groups, and the expression of p-moesin of Group E was significantly lower than that of Group D (P < 0.05). Electron microcopy showed that the liver sinusoids of the mice in Group E was significantly better compared with the other groups, and there was no significant difference between Groups B and D.An upregulation of RhoGTPase that contributes to increased CTGF expression and phosphorylation of moesin may induce a transition of liver sinusoidal endothelial cells in schistosomiasis." @default.
- W2401476471 created "2016-06-24" @default.
- W2401476471 creator A5038386404 @default.
- W2401476471 creator A5044083934 @default.
- W2401476471 creator A5044396395 @default.
- W2401476471 creator A5063319643 @default.
- W2401476471 creator A5070933154 @default.
- W2401476471 date "2007-06-12" @default.
- W2401476471 modified "2023-09-23" @default.
- W2401476471 title "[Regulatory effects of RhoGTPase on transition of liver sinusoidal capillarization: experiment with mice of schistosomal hepatic fibrosis]." @default.
- W2401476471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17785114" @default.
- W2401476471 hasPublicationYear "2007" @default.
- W2401476471 type Work @default.
- W2401476471 sameAs 2401476471 @default.
- W2401476471 citedByCount "0" @default.
- W2401476471 crossrefType "journal-article" @default.
- W2401476471 hasAuthorship W2401476471A5038386404 @default.
- W2401476471 hasAuthorship W2401476471A5044083934 @default.
- W2401476471 hasAuthorship W2401476471A5044396395 @default.
- W2401476471 hasAuthorship W2401476471A5063319643 @default.
- W2401476471 hasAuthorship W2401476471A5070933154 @default.
- W2401476471 hasConcept C126322002 @default.
- W2401476471 hasConcept C134018914 @default.
- W2401476471 hasConcept C170493617 @default.
- W2401476471 hasConcept C204232928 @default.
- W2401476471 hasConcept C2775960820 @default.
- W2401476471 hasConcept C2777093181 @default.
- W2401476471 hasConcept C2780559512 @default.
- W2401476471 hasConcept C2780631158 @default.
- W2401476471 hasConcept C2993667909 @default.
- W2401476471 hasConcept C55493867 @default.
- W2401476471 hasConcept C62478195 @default.
- W2401476471 hasConcept C71924100 @default.
- W2401476471 hasConcept C86803240 @default.
- W2401476471 hasConceptScore W2401476471C126322002 @default.
- W2401476471 hasConceptScore W2401476471C134018914 @default.
- W2401476471 hasConceptScore W2401476471C170493617 @default.
- W2401476471 hasConceptScore W2401476471C204232928 @default.
- W2401476471 hasConceptScore W2401476471C2775960820 @default.
- W2401476471 hasConceptScore W2401476471C2777093181 @default.
- W2401476471 hasConceptScore W2401476471C2780559512 @default.
- W2401476471 hasConceptScore W2401476471C2780631158 @default.
- W2401476471 hasConceptScore W2401476471C2993667909 @default.
- W2401476471 hasConceptScore W2401476471C55493867 @default.
- W2401476471 hasConceptScore W2401476471C62478195 @default.
- W2401476471 hasConceptScore W2401476471C71924100 @default.
- W2401476471 hasConceptScore W2401476471C86803240 @default.
- W2401476471 hasIssue "22" @default.
- W2401476471 hasLocation W24014764711 @default.
- W2401476471 hasOpenAccess W2401476471 @default.
- W2401476471 hasPrimaryLocation W24014764711 @default.
- W2401476471 hasRelatedWork W2347580972 @default.
- W2401476471 hasRelatedWork W2349211122 @default.
- W2401476471 hasRelatedWork W2351552441 @default.
- W2401476471 hasRelatedWork W2378683446 @default.
- W2401476471 hasRelatedWork W2384284049 @default.
- W2401476471 hasRelatedWork W2395547334 @default.
- W2401476471 hasRelatedWork W2416707095 @default.
- W2401476471 hasRelatedWork W2884565145 @default.
- W2401476471 hasRelatedWork W2980702830 @default.
- W2401476471 hasRelatedWork W3001847241 @default.
- W2401476471 hasRelatedWork W3030332626 @default.
- W2401476471 hasRelatedWork W3030693463 @default.
- W2401476471 hasRelatedWork W3031570653 @default.
- W2401476471 hasRelatedWork W3031667522 @default.
- W2401476471 hasRelatedWork W3031916893 @default.
- W2401476471 hasRelatedWork W3139550883 @default.
- W2401476471 hasRelatedWork W3148119073 @default.
- W2401476471 hasRelatedWork W3183485520 @default.
- W2401476471 hasRelatedWork W47135889 @default.
- W2401476471 hasRelatedWork W3029373240 @default.
- W2401476471 hasVolume "87" @default.
- W2401476471 isParatext "false" @default.
- W2401476471 isRetracted "false" @default.
- W2401476471 magId "2401476471" @default.
- W2401476471 workType "article" @default.