Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401486397> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2401486397 endingPage "3335" @default.
- W2401486397 startingPage "3327" @default.
- W2401486397 abstract "The recently discovered cytokine, interleukin-15 (IL-15), has been demonstrated to share several biologic properties with IL-2 in different cell systems, including T-cell and natural killer (NK) cell compartments. As for B lymphocytes, IL-15 has been shown to provide stimulatory activities in normal preactivated B cells that are mainly transduced through IL- 2 receptor (IL-2R) complex components. Since leukemic B cells from patients with chronic lymphoproliferative disorders (CLD) bear IL-2R and grow in response to IL-2, we investigated whether IL-15 triggers the proliferation of malignant B cells obtained from 12 patients with B-cell chronic lymphocytic leukemia (B-CLL) and five patients with hairy cell leukemia (HCL). Enriched B cells recovered from five healthy subjects were also studied as controls. IL-15 stimulated the proliferation of freshly isolated leukemic B cells, but not resting normal B lymphocytes, the latter being able to grow in the presence of IL-15 only after in vitro preactivation with phorbol myristate acetate. The proliferation elicited by IL-2 on leukemic cells was comparable to that determined by IL-15. Following addition of graded concentrations of IL-15 to low/intermediate-dose IL-2, resting leukemic B cells showed a higher stimulatory rate than that observed using the two cytokines separately. In normal resting B lymphocytes, this cumulative effect was not observed. The role of different IL-2R subunits in IL-15-driven growth of malignant B cells was investigated both by their expression on leukemic cells and by the block of different IL-2R subunits (p55, p75, and p64) with specific monoclonal antibodies (MoAbs). Using flow cytometry and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses we demonstrated that both B-CLL and HCL leukemic B cells express the beta and gamma chains of the IL-2R system. The stimulatory activity achieved by IL-15 decreased significantly, blocking the beta and gamma chains of the IL-2R. Taken together, these findings demonstrate that IL-15 triggers the growth of leukemic B cells through IL-2R system subunits, pointing to the role of this novel cytokine in regulating the neoplastic proliferation in CLD." @default.
- W2401486397 created "2016-06-24" @default.
- W2401486397 creator A5011398547 @default.
- W2401486397 creator A5013236194 @default.
- W2401486397 creator A5013529815 @default.
- W2401486397 creator A5034083668 @default.
- W2401486397 creator A5035315874 @default.
- W2401486397 creator A5038209973 @default.
- W2401486397 creator A5042259231 @default.
- W2401486397 creator A5066814162 @default.
- W2401486397 creator A5086902762 @default.
- W2401486397 creator A5087722204 @default.
- W2401486397 date "1996-04-15" @default.
- W2401486397 modified "2023-10-17" @default.
- W2401486397 title "Interleukin-15 promotes the growth of leukemic cells of patients with B- cell chronic lymphoproliferative disorders" @default.
- W2401486397 doi "https://doi.org/10.1182/blood.v87.8.3327.bloodjournal8783327" @default.
- W2401486397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8605349" @default.
- W2401486397 hasPublicationYear "1996" @default.
- W2401486397 type Work @default.
- W2401486397 sameAs 2401486397 @default.
- W2401486397 citedByCount "85" @default.
- W2401486397 countsByYear W24014863972012 @default.
- W2401486397 countsByYear W24014863972013 @default.
- W2401486397 countsByYear W24014863972014 @default.
- W2401486397 countsByYear W24014863972015 @default.
- W2401486397 countsByYear W24014863972016 @default.
- W2401486397 countsByYear W24014863972017 @default.
- W2401486397 countsByYear W24014863972021 @default.
- W2401486397 countsByYear W24014863972022 @default.
- W2401486397 countsByYear W24014863972023 @default.
- W2401486397 crossrefType "journal-article" @default.
- W2401486397 hasAuthorship W2401486397A5011398547 @default.
- W2401486397 hasAuthorship W2401486397A5013236194 @default.
- W2401486397 hasAuthorship W2401486397A5013529815 @default.
- W2401486397 hasAuthorship W2401486397A5034083668 @default.
- W2401486397 hasAuthorship W2401486397A5035315874 @default.
- W2401486397 hasAuthorship W2401486397A5038209973 @default.
- W2401486397 hasAuthorship W2401486397A5042259231 @default.
- W2401486397 hasAuthorship W2401486397A5066814162 @default.
- W2401486397 hasAuthorship W2401486397A5086902762 @default.
- W2401486397 hasAuthorship W2401486397A5087722204 @default.
- W2401486397 hasBestOaLocation W24014863971 @default.
- W2401486397 hasConcept C153911025 @default.
- W2401486397 hasConcept C159654299 @default.
- W2401486397 hasConcept C203014093 @default.
- W2401486397 hasConcept C2776995267 @default.
- W2401486397 hasConcept C2777938653 @default.
- W2401486397 hasConcept C2778453870 @default.
- W2401486397 hasConcept C2778461978 @default.
- W2401486397 hasConcept C2778690821 @default.
- W2401486397 hasConcept C2779338263 @default.
- W2401486397 hasConcept C2780483514 @default.
- W2401486397 hasConcept C55493867 @default.
- W2401486397 hasConcept C62112901 @default.
- W2401486397 hasConcept C86803240 @default.
- W2401486397 hasConceptScore W2401486397C153911025 @default.
- W2401486397 hasConceptScore W2401486397C159654299 @default.
- W2401486397 hasConceptScore W2401486397C203014093 @default.
- W2401486397 hasConceptScore W2401486397C2776995267 @default.
- W2401486397 hasConceptScore W2401486397C2777938653 @default.
- W2401486397 hasConceptScore W2401486397C2778453870 @default.
- W2401486397 hasConceptScore W2401486397C2778461978 @default.
- W2401486397 hasConceptScore W2401486397C2778690821 @default.
- W2401486397 hasConceptScore W2401486397C2779338263 @default.
- W2401486397 hasConceptScore W2401486397C2780483514 @default.
- W2401486397 hasConceptScore W2401486397C55493867 @default.
- W2401486397 hasConceptScore W2401486397C62112901 @default.
- W2401486397 hasConceptScore W2401486397C86803240 @default.
- W2401486397 hasIssue "8" @default.
- W2401486397 hasLocation W24014863971 @default.
- W2401486397 hasOpenAccess W2401486397 @default.
- W2401486397 hasPrimaryLocation W24014863971 @default.
- W2401486397 hasRelatedWork W2010674671 @default.
- W2401486397 hasRelatedWork W2019248715 @default.
- W2401486397 hasRelatedWork W2080115119 @default.
- W2401486397 hasRelatedWork W2418031697 @default.
- W2401486397 hasRelatedWork W2419275542 @default.
- W2401486397 hasRelatedWork W2427404340 @default.
- W2401486397 hasRelatedWork W2439278013 @default.
- W2401486397 hasRelatedWork W2616904198 @default.
- W2401486397 hasRelatedWork W579273576 @default.
- W2401486397 hasRelatedWork W97482242 @default.
- W2401486397 hasVolume "87" @default.
- W2401486397 isParatext "false" @default.
- W2401486397 isRetracted "false" @default.
- W2401486397 magId "2401486397" @default.
- W2401486397 workType "article" @default.