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- W2401492098 startingPage "F647" @default.
- W2401492098 abstract "This Editorial Review describes the mechanisms that have been identified for mediating active H + secretion across the luminal membrane of the proximal tubular cell. These include Na+-H+ exchange, Na+-phosphate cotransport, organic anion-OH- exchange, ATP-driven H+ transport, and redox-driven H+ transport. Of these, Na+-H+ exchange appears to bethe most important. Indeed, there is no conclusive evidence against the concept that luminal membrane Na+-H- exchange is the principal if not the sole mechanism for mediating active H+ secretion in the proximal tubule. The transport properties of the Na+-H+ exchanger, particularly its striking sensitivity to intracellular pH, can explain many aspects of howthe rate of active H+ secretion in the proximal tubule is regulated in response to various physiologic stimuli. Certainly, important physiologic roles for other H+ secretory mechanisms, especially those involving primary active H+ secretion,have not been excluded. Nevertheless, there is not yet definitive proof that ATP-driven or redox-driven H+ pumps are located on the luminal membrane itself or that they significantly contribute to transtubular H+ secretion." @default.
- W2401492098 created "2016-06-24" @default.
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- W2401492098 date "1983-12-01" @default.
- W2401492098 modified "2023-10-16" @default.
- W2401492098 title "Mechanisms of active H+ secretion in the proximal tubule" @default.
- W2401492098 doi "https://doi.org/10.1152/ajprenal.1983.245.6.f647" @default.
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