Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401497788> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2401497788 endingPage "16" @default.
- W2401497788 startingPage "609" @default.
- W2401497788 abstract "Among many drugs used for treatment of obsessive-compulsive disorder clomipramine is still considered as model drug though serotoninergic mechanism is common for many antidepressants. The study was carried out in order to assess the potential and dynamic of antiobsessive and anticompulsive efficacy of clomipramine used in normal therapeutic doses during eight week trial. The study was carried out with the help of Asta Medica company and trade name of the used drug was Hydiphen. The severity of obsessive-compulsive disorder was evaluated at the moment of inclusion to the study and then once every week. The obsessive-compulsive scale Y-BOCS was employed. 27 patietnts (16 women and 11 men) at aged 18-64, from different mental health care centers in Poland participated in this study. The study was completed by 67% of patients--due to lack of therapeutical effect the treatment of others patients was stopped. Among the patients who responded well to clomipramine therapy, improvement was observed after the first week and then the dynamic of improvement decreased after 4 weeks. During the 7th week the drug reached its maximal efficacy level with statistically significant reduction in scores of Y-BOCS scale. The range of therapeutic doses was 75-250 mg. In this range no seriouse adverse events were observed and some of mild ones that occurred at the beginning of the therapy diminished during the next week." @default.
- W2401497788 created "2016-06-24" @default.
- W2401497788 creator A5041552894 @default.
- W2401497788 creator A5044074957 @default.
- W2401497788 creator A5059105945 @default.
- W2401497788 date "2000-04-29" @default.
- W2401497788 modified "2023-09-23" @default.
- W2401497788 title "[Clomipramine in the treatment of obsessive-compulsive disorder. An open 8-week trial]." @default.
- W2401497788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10786252" @default.
- W2401497788 hasPublicationYear "2000" @default.
- W2401497788 type Work @default.
- W2401497788 sameAs 2401497788 @default.
- W2401497788 citedByCount "0" @default.
- W2401497788 crossrefType "journal-article" @default.
- W2401497788 hasAuthorship W2401497788A5041552894 @default.
- W2401497788 hasAuthorship W2401497788A5044074957 @default.
- W2401497788 hasAuthorship W2401497788A5059105945 @default.
- W2401497788 hasConcept C118552586 @default.
- W2401497788 hasConcept C126322002 @default.
- W2401497788 hasConcept C197934379 @default.
- W2401497788 hasConcept C2779305415 @default.
- W2401497788 hasConcept C3017582312 @default.
- W2401497788 hasConcept C500440147 @default.
- W2401497788 hasConcept C535046627 @default.
- W2401497788 hasConcept C71924100 @default.
- W2401497788 hasConceptScore W2401497788C118552586 @default.
- W2401497788 hasConceptScore W2401497788C126322002 @default.
- W2401497788 hasConceptScore W2401497788C197934379 @default.
- W2401497788 hasConceptScore W2401497788C2779305415 @default.
- W2401497788 hasConceptScore W2401497788C3017582312 @default.
- W2401497788 hasConceptScore W2401497788C500440147 @default.
- W2401497788 hasConceptScore W2401497788C535046627 @default.
- W2401497788 hasConceptScore W2401497788C71924100 @default.
- W2401497788 hasIssue "4" @default.
- W2401497788 hasLocation W24014977881 @default.
- W2401497788 hasOpenAccess W2401497788 @default.
- W2401497788 hasPrimaryLocation W24014977881 @default.
- W2401497788 hasRelatedWork W1966721652 @default.
- W2401497788 hasRelatedWork W1971097055 @default.
- W2401497788 hasRelatedWork W1990674736 @default.
- W2401497788 hasRelatedWork W2011121134 @default.
- W2401497788 hasRelatedWork W2016098981 @default.
- W2401497788 hasRelatedWork W2042829752 @default.
- W2401497788 hasRelatedWork W2112258504 @default.
- W2401497788 hasRelatedWork W2153828769 @default.
- W2401497788 hasRelatedWork W2167099737 @default.
- W2401497788 hasRelatedWork W2282192107 @default.
- W2401497788 hasVolume "33" @default.
- W2401497788 isParatext "false" @default.
- W2401497788 isRetracted "false" @default.
- W2401497788 magId "2401497788" @default.
- W2401497788 workType "article" @default.