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- W2401586592 abstract "Objective To investigate the distribution of various anti-anionic and anti-cofactor phospholipid antibodies in children with kala-azar, and to compare them to malaria, toxoplasmosis and auto-immune disease. Patients and Methods The frequency and the concentration of antibodies against cardiolipin (aCL), phosphatidylserine (aPS), phosphatidylinositol (aPI), phosphatidic acid (aPA), β2GPI (antiβ2GPI (antiβ β2GPI), prothrombin (aPT), annexin V (aAnnV), protein C (aPnC) and protein β2GPI), prothrombin (aPT), annexin V (aAnnV), protein C (aPnC) and protein β S (aPnS) were studied in sera from 103 children with kala-azar and compared with malaria (n=32), toxoplasmosis (n=31), systemic lupus erythematosus (SLE) (n=40) and antiphospholipid syndrome (APS) (n=35). Results The prevalence of aCL, aPS, aPI, aPA, anti-β2GPI, aPT, aAnnV, aPnC and aPnS was 54%, 56%, 43%, 28%, 73%, 67%, β2GPI, aPT, aAnnV, aPnC and aPnS was 54%, 56%, 43%, 28%, 73%, 67%, β 55%, 30%, 25%, respectively. Ninety-three per cent of children with kala-azar (96/103) had one or more aPL specifi cities, but none had thromboses. The spectrum of aPL was quite similar to that found in patients with SLE and APS. Conclusion Antiphospholipid antibodies are a frequent fi nding in kala-azar. The aPL produced mimic those found in autoimmune disease. However, further studies are required to assess the exact role of these aPL during leishmaniasis." @default.
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- W2401586592 date "2008-09-01" @default.
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- W2401586592 title "Antibodies to anionic phospholipids and cofactors in kala-azar. Comparative study with malaria, toxoplasmosis and autoimmune diseases." @default.
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