FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401644992> ?p ?o ?g. }

• W2401644992 endingPage "4629" @default.
• W2401644992 startingPage "4620" @default.
• W2401644992 abstract "ABSTRACT The clinical impact of infections with respiratory viruses belonging to the family Paramyxoviridae argues for the development of antiviral therapies with broad-spectrum activity. Favipiravir (T-705) has demonstrated potent antiviral activity against multiple RNA virus families and is presently in clinical evaluation for the treatment of influenza. Here we demonstrate in vitro activity of T-705 against the paramyxoviruses human metapneumovirus (HMPV), respiratory syncytial virus, human parainfluenza virus, measles virus, Newcastle disease virus, and avian metapneumovirus. In addition, we demonstrate activity against HMPV in hamsters. T-705 treatment inhibited replication of all paramyxoviruses tested in vitro , with 90% effective concentration (EC 90 ) values of 8 to 40 μM. Treatment of HMPV-challenged hamsters with T-705 at 200 mg/kg of body weight/day resulted in 100% protection from infection of the lungs. In all treated and challenged animals, viral RNA remained detectable in the respiratory tract. The observation that T-705 treatment had a significant effect on infectious viral titers, with a limited effect on viral genome titers, is in agreement with its proposed mode of action of viral mutagenesis. However, next-generation sequencing of viral genomes isolated from treated and challenged hamsters did not reveal (hyper)mutation. Polymerase activity assays revealed a specific effect of T-705 on the activity of the HMPV polymerase. With the reported antiviral activity of T-705 against a broad range of RNA virus families, this small molecule is a promising broad-range antiviral drug candidate for limiting the viral burden of paramyxoviruses and for evaluation for treatment of infections with (re)emerging viruses, such as the henipaviruses." @default.
• W2401644992 created "2016-06-24" @default.
• W2401644992 creator A5020748899 @default.
• W2401644992 creator A5033922663 @default.
• W2401644992 creator A5061422369 @default.
• W2401644992 creator A5073105044 @default.
• W2401644992 creator A5078395184 @default.
• W2401644992 creator A5089010495 @default.
• W2401644992 date "2016-08-01" @default.
• W2401644992 modified "2023-10-12" @default.
• W2401644992 title "Antiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses <i>In Vitro</i> and against Human Metapneumovirus in Hamsters" @default.
• W2401644992 cites W1826790168 @default.
• W2401644992 cites W1971292277 @default.
• W2401644992 cites W1981329413 @default.
• W2401644992 cites W1986189079 @default.
• W2401644992 cites W1986557750 @default.
• W2401644992 cites W2002076019 @default.
• W2401644992 cites W2007293904 @default.
• W2401644992 cites W2013539008 @default.
• W2401644992 cites W2018928802 @default.
• W2401644992 cites W2022434050 @default.
• W2401644992 cites W2027116420 @default.
• W2401644992 cites W2037162459 @default.
• W2401644992 cites W2039941020 @default.
• W2401644992 cites W2043023693 @default.
• W2401644992 cites W2050169388 @default.
• W2401644992 cites W2052305185 @default.
• W2401644992 cites W2053449086 @default.
• W2401644992 cites W2058203122 @default.
• W2401644992 cites W2060514161 @default.
• W2401644992 cites W2079845690 @default.
• W2401644992 cites W2087048911 @default.
• W2401644992 cites W2093964315 @default.
• W2401644992 cites W2102146833 @default.
• W2401644992 cites W2108367829 @default.
• W2401644992 cites W2113629675 @default.
• W2401644992 cites W2114064040 @default.
• W2401644992 cites W2122295310 @default.
• W2401644992 cites W2126245676 @default.
• W2401644992 cites W2128145141 @default.
• W2401644992 cites W2129165766 @default.
• W2401644992 cites W2130620055 @default.
• W2401644992 cites W2132136988 @default.
• W2401644992 cites W2132881916 @default.
• W2401644992 cites W2133965262 @default.
• W2401644992 cites W2134348918 @default.
• W2401644992 cites W2137569894 @default.
• W2401644992 cites W2138274210 @default.
• W2401644992 cites W2138992015 @default.
• W2401644992 cites W2140965090 @default.
• W2401644992 cites W2141040082 @default.
• W2401644992 cites W2154270538 @default.
• W2401644992 cites W2156788262 @default.
• W2401644992 cites W2161121438 @default.
• W2401644992 cites W2161293269 @default.
• W2401644992 cites W2162699926 @default.
• W2401644992 cites W2163537732 @default.
• W2401644992 cites W2166280456 @default.
• W2401644992 cites W2166596830 @default.
• W2401644992 cites W2170197010 @default.
• W2401644992 cites W4237567990 @default.
• W2401644992 cites W4249605191 @default.
• W2401644992 doi "https://doi.org/10.1128/aac.00709-16" @default.
• W2401644992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4958190" @default.
• W2401644992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27185803" @default.
• W2401644992 hasPublicationYear "2016" @default.
• W2401644992 type Work @default.
• W2401644992 sameAs 2401644992 @default.
• W2401644992 citedByCount "39" @default.
• W2401644992 countsByYear W24016449922016 @default.
• W2401644992 countsByYear W24016449922017 @default.
• W2401644992 countsByYear W24016449922018 @default.
• W2401644992 countsByYear W24016449922019 @default.
• W2401644992 countsByYear W24016449922020 @default.
• W2401644992 countsByYear W24016449922021 @default.
• W2401644992 countsByYear W24016449922022 @default.
• W2401644992 countsByYear W24016449922023 @default.
• W2401644992 crossrefType "journal-article" @default.
• W2401644992 hasAuthorship W2401644992A5020748899 @default.
• W2401644992 hasAuthorship W2401644992A5033922663 @default.
• W2401644992 hasAuthorship W2401644992A5061422369 @default.
• W2401644992 hasAuthorship W2401644992A5073105044 @default.
• W2401644992 hasAuthorship W2401644992A5078395184 @default.
• W2401644992 hasAuthorship W2401644992A5089010495 @default.
• W2401644992 hasBestOaLocation W24016449921 @default.
• W2401644992 hasConcept C105702510 @default.
• W2401644992 hasConcept C140704245 @default.
• W2401644992 hasConcept C142724271 @default.
• W2401644992 hasConcept C159047783 @default.
• W2401644992 hasConcept C2522874641 @default.
• W2401644992 hasConcept C2776012195 @default.
• W2401644992 hasConcept C2779134260 @default.
• W2401644992 hasConcept C2779756493 @default.
• W2401644992 hasConcept C2779772310 @default.
• W2401644992 hasConcept C2780475896 @default.
• W2401644992 hasConcept C2780727368 @default.
• W2401644992 hasConcept C2780813555 @default.
• W2401644992 hasConcept C2781445406 @default.

• next