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- W2401661856 abstract "The authors studied ranitidine effects on the function of glucocorticoid receptors (GR) of gastric cytosol in patients with massive bleeding from gastric ulcer. Fast cytosol was obtained from the tissues taken from the great culvature of the resected stomach. GR type II and III were identified using 3H-acetonide triamcinolone and 3H-hydrocortisone with high specific activity, respectively. Ranitidine (10(-3) and 10(-2) M) effects on the function of GR type II and III were analyzed according to Scatchard. Ranitidine (10(-2) M) increased 4 times the number of sites of glucocorticoid receptor binding for acetonide triamcinolone and aroused the association constant of hormone-receptor complex. Ranitidine dose-dependently reduced the number of binding sites of GR type III for hydrocortisone. Thus, ranitidine modulates type II and III GR function." @default.
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- W2401661856 date "1998-02-21" @default.
- W2401661856 modified "2023-09-23" @default.
- W2401661856 title "[Effect of ranitidine on the function of the gastric glucocorticoid receptors]." @default.
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