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• W2401677811 endingPage "2267" @default.
• W2401677811 startingPage "2260" @default.
• W2401677811 abstract "Physical hydrogels are extensively used in a wide range of biomedical applications. However, different applications require hydrogels with different mechanical and structural properties. Tailoring these properties demands exquisite control over the supramolecular interactions involved. Here we show that it is possible to control the mechanical properties of hydrogels using de novo designed coiled coil peptides with different affinities for dimerization. Four different nonorthogonal peptides, designed to fold into four different coiled coil heterodimers with dissociation constants spanning from μM to pM, were conjugated to star-shaped 4-arm poly(ethylene glycol) (PEG). The different PEG-coiled coil conjugates self-assemble as a result of peptide heterodimerization. Different combinations of PEG–peptide conjugates assemble into PEG–peptide networks and hydrogels with distinctly different thermal stabilities, supramolecular, and rheological properties, reflecting the peptide dimer affinities. We also demonstrate that it is possible to rationally modulate the self-assembly process by means of thermodynamic self-sorting by sequential additions of nonpegylated peptides. The specific interactions involved in peptide dimerization thus provides means for programmable and reversible self-assembly of hydrogels with precise control over rheological properties, which can significantly facilitate optimization of their overall performance and adaption to different processing requirements and applications." @default.
• W2401677811 created "2016-06-24" @default.
• W2401677811 creator A5033045367 @default.
• W2401677811 creator A5062117986 @default.
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• W2401677811 date "2016-06-02" @default.
• W2401677811 modified "2023-10-10" @default.
• W2401677811 title "Tailoring Supramolecular Peptide–Poly(ethylene glycol) Hydrogels by Coiled Coil Self-Assembly and Self-Sorting" @default.
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• W2401677811 doi "https://doi.org/10.1021/acs.biomac.6b00528" @default.
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• W2401677811 hasPublicationYear "2016" @default.
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