Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401681776> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2401681776 endingPage "861" @default.
- W2401681776 startingPage "857" @default.
- W2401681776 abstract "Summary KRDS, a tetrapeptide from human lactotransferrin, inhibits thrombin-induced platelet aggregation, secretion and thromboxane (TX) synthesis without interfering with phospholipase C (PLC) β activation, since in previous work we have shown that Ca2+ mobilization and phosphorylation of the myosin light chain kinase (20 kDa) and pleckstrin (47 kDa) were normal. However, the inhibition of arachido- nic acid-induced aggregation in the presence of KRDS is accompanied by normal TX synthesis suggesting that it does not interfere with the cyclooxygenase activity. To elucidate further the mechanisms of action of this peptide we tested its effect on U46619-induced platelet activation. KRDS inhibits U46619-induced platelet aggregation time- and dose-dependently without inhibiting the phosphorylation of pleckstrin. This suggests that the PLC pathway is not affected and that the inhibitory effect of KRDS is not due to an uncoupling of TXA2 from its receptor. In addition to the PLC pathway, protein tyrosine kinases play a major role in platelet signal transduction mechanisms. At least 7 tyrosine-phosphorylated proteins are detected upon stimulation of platelets by thrombin. KRDS strongly inhibits the tyrosine- phosphorylated substrates, in particular two 100-105 kDa substrates which are related to GP Ilb/IIIa activation and platelet aggregation. The absence of TX synthesis observed in the presence of KRDS could be due to the inactivation of cPLA2 since the latter needs tyrosine phosphorylation to be activated, thus explaining the inhibitory action of KRDS on platelet functions." @default.
- W2401681776 created "2016-06-24" @default.
- W2401681776 creator A5029654987 @default.
- W2401681776 creator A5082748449 @default.
- W2401681776 creator A5088588580 @default.
- W2401681776 creator A5091290798 @default.
- W2401681776 date "1995-01-01" @default.
- W2401681776 modified "2023-10-17" @default.
- W2401681776 title "KRDS, a Peptide Derived from Human Lactotransferrin, Inhibits Thrombin-Induced Thromboxane Synthesis by a Cyclooxygenase-Independent Mechanism" @default.
- W2401681776 doi "https://doi.org/10.1055/s-0038-1653881" @default.
- W2401681776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7482416" @default.
- W2401681776 hasPublicationYear "1995" @default.
- W2401681776 type Work @default.
- W2401681776 sameAs 2401681776 @default.
- W2401681776 citedByCount "11" @default.
- W2401681776 countsByYear W24016817762012 @default.
- W2401681776 countsByYear W24016817762013 @default.
- W2401681776 countsByYear W24016817762014 @default.
- W2401681776 countsByYear W24016817762018 @default.
- W2401681776 countsByYear W24016817762019 @default.
- W2401681776 crossrefType "journal-article" @default.
- W2401681776 hasAuthorship W2401681776A5029654987 @default.
- W2401681776 hasAuthorship W2401681776A5082748449 @default.
- W2401681776 hasAuthorship W2401681776A5088588580 @default.
- W2401681776 hasAuthorship W2401681776A5091290798 @default.
- W2401681776 hasConcept C11960822 @default.
- W2401681776 hasConcept C170493617 @default.
- W2401681776 hasConcept C185592680 @default.
- W2401681776 hasConcept C195794163 @default.
- W2401681776 hasConcept C203014093 @default.
- W2401681776 hasConcept C2776785769 @default.
- W2401681776 hasConcept C2777292125 @default.
- W2401681776 hasConcept C2777553839 @default.
- W2401681776 hasConcept C2778597717 @default.
- W2401681776 hasConcept C2781024287 @default.
- W2401681776 hasConcept C3018697912 @default.
- W2401681776 hasConcept C51603380 @default.
- W2401681776 hasConcept C55493867 @default.
- W2401681776 hasConcept C62478195 @default.
- W2401681776 hasConcept C85528070 @default.
- W2401681776 hasConcept C86803240 @default.
- W2401681776 hasConcept C89560881 @default.
- W2401681776 hasConcept C95444343 @default.
- W2401681776 hasConceptScore W2401681776C11960822 @default.
- W2401681776 hasConceptScore W2401681776C170493617 @default.
- W2401681776 hasConceptScore W2401681776C185592680 @default.
- W2401681776 hasConceptScore W2401681776C195794163 @default.
- W2401681776 hasConceptScore W2401681776C203014093 @default.
- W2401681776 hasConceptScore W2401681776C2776785769 @default.
- W2401681776 hasConceptScore W2401681776C2777292125 @default.
- W2401681776 hasConceptScore W2401681776C2777553839 @default.
- W2401681776 hasConceptScore W2401681776C2778597717 @default.
- W2401681776 hasConceptScore W2401681776C2781024287 @default.
- W2401681776 hasConceptScore W2401681776C3018697912 @default.
- W2401681776 hasConceptScore W2401681776C51603380 @default.
- W2401681776 hasConceptScore W2401681776C55493867 @default.
- W2401681776 hasConceptScore W2401681776C62478195 @default.
- W2401681776 hasConceptScore W2401681776C85528070 @default.
- W2401681776 hasConceptScore W2401681776C86803240 @default.
- W2401681776 hasConceptScore W2401681776C89560881 @default.
- W2401681776 hasConceptScore W2401681776C95444343 @default.
- W2401681776 hasIssue "05" @default.
- W2401681776 hasLocation W24016817761 @default.
- W2401681776 hasLocation W24016817762 @default.
- W2401681776 hasOpenAccess W2401681776 @default.
- W2401681776 hasPrimaryLocation W24016817761 @default.
- W2401681776 hasRelatedWork W1964894777 @default.
- W2401681776 hasRelatedWork W2076672409 @default.
- W2401681776 hasRelatedWork W2088739608 @default.
- W2401681776 hasRelatedWork W2153396160 @default.
- W2401681776 hasRelatedWork W2171151327 @default.
- W2401681776 hasRelatedWork W2266611621 @default.
- W2401681776 hasRelatedWork W2401681776 @default.
- W2401681776 hasRelatedWork W2414570195 @default.
- W2401681776 hasRelatedWork W2416389075 @default.
- W2401681776 hasRelatedWork W2901754190 @default.
- W2401681776 hasVolume "73" @default.
- W2401681776 isParatext "false" @default.
- W2401681776 isRetracted "false" @default.
- W2401681776 magId "2401681776" @default.
- W2401681776 workType "article" @default.