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• W2401722928 abstract "A pathologic hallmark of Huntington disease (HD) is the presence of intraneuronal aggregates of polyglutamine-containing huntingtin protein fragments. Monoclonal antibody 1C2 is a commercial antibody to normal human TATA-binding protein that detects long stretches of glutamine residues. Using 1C2 as a surrogate marker formutant huntingtin protein, we immunostained 19 HD cases, 10 normal controls, and 10 cases of frontotemporal degeneration with ubiquitinated inclusions as diseased controls. In the HD cases, there was consistent 1C2 immunoreactivity in the neocortex, striatum, hippocampus, lateral geniculate body, basis pontis, medullary reticular formation, and cerebellar dentate nucleus. The normal and diseased controls demonstrated 1C2 immunoreactivity only in the substantia nigra, locus coeruleus, and pituitary gland. Staining of 5 HD cases and 5 normal controls revealed a less consistent and less diagnostically useful morphologic immunoreactivity profile. These results indicate that widespread 1C2 immunoreactivity is present in diverse central nervous system areas in HD, and that in the appropriate setting, 1C2 staining can be a useful tool in the postmortem diagnosis of HD when neuromelanin-containing neuronal populations are avoided." @default.
• W2401722928 created "2016-06-24" @default.
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• W2401722928 date "2009-03-01" @default.
• W2401722928 modified "2023-10-14" @default.
• W2401722928 title "Neuroanatomic Profile of Polyglutamine Immunoreactivity in Huntington Disease Brains" @default.
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• W2401722928 doi "https://doi.org/10.1097/nen.0b013e318198d320" @default.
• W2401722928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756075" @default.
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