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- W2401744206 abstract "Human T cells can be genetically modified to express tumor-associated antigens (TAA) for the induction of tumor-specific immunity, suggesting that T cells may be alternative candidates of effective antigen-presenting cells (TAPC) and may be useful in vivo as cellular cancer vaccines. The effective induction of TAA-specific T cell immune responses requires activation of T cells by CD3/CD28 antibodies and the presence of proinflammatory cytokines such as interleukin-7 (IL-7) and interleukin-12 (IL-12). Here, we describe the technique of preparing activated human TAPC pulsed with TAA peptides for the induction of tumor antigen-specific T cell immunity in vitro." @default.
- W2401744206 created "2016-06-24" @default.
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- W2401744206 date "2014-01-01" @default.
- W2401744206 modified "2023-09-25" @default.
- W2401744206 title "Modification of T Lymphocytes to Express Tumor Antigens" @default.
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- W2401744206 doi "https://doi.org/10.1007/978-1-4939-0345-0_15" @default.
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