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- W2401747108 abstract "Objective. To study the contribution of the CD14 gene to the pathogenesis of rheumatoid arthritis (RA) in Japanese patients. Methods. CD14 genotyping was carried out at the -159C/T dimorphic site in 97 RA patients and 104 normal subjects by the PCR-RFLP (restriction fragment length polymorphism) method. HLA-DRB1 genotyping was performed by the PCR-SSCP (sequence specific conformational polymorphism) method. Results. The -159C/T dimorphism is not associated with whole RA or with female RA, and the results were compatible with a previous report from Germany. The -159C/T dimorphism was not associated with rheumatoid factor (RF)-positive RA, although the -159T allele tended to be associated with RF in the German report. The -159C/T dimorphism showed no association even in RA patients with the RA-susceptibility HLA-DRB1 *0405. The -159T allele was prevalent in Japanese controls. Conclusion. The CD14 gene is very unlikely to be genetically involved in the pathogenesis of Japanese RA." @default.
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- W2401747108 date "2008-03-01" @default.
- W2401747108 modified "2023-10-02" @default.
- W2401747108 title "Genetic contribution of the CD14 -159C/T dimorphism in the promoter region in Japanese RA." @default.
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