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• W2401786787 abstract "systemic lupus erythematosus (SLE) in pregnancy is associated with increased maternal and fetal morbidity including fetal loss, growth restriction, and maternal hypertension. Pregnancy complications are more frequent and more severe when conception occurs in patients with lupus nephritis or antiphospholipid antibodies, or during a period of active disease. Lupus flares occur in the majority of pregnancies and often involve the renal and haematologis systems. They tend to be mild to moderate and are treatable with medical therapy, primarily glucocorticoids. Neonatal lupus syndrome is a rare complication of maternal SLE. It is associated with transplacental passage of anti-Ro and/or anti-La antibodies, resulting in cutaneous, haematologic, and cardiac manifestations. Cardiac involvement is common in this syndrome, manifesting as complete congenital heart block due to destruction of the fetal conduction system by antibodies. Antepartum steroid use may be useful in treatment or prevention of congenital heart block. With optimal prenatal care and fetal antepartum surveillance, patients with SLE may have successful, although high risk, pregnancies. le lupus érythémateux disséminé (LED) durant la grossesse est responsable d’une morbidité maternelle et fœtale de plus en plus fréquente qui comprend la perte du fœtus, les retards de croissance et l’hypertension maternelle. Les complications durant la grossesse sont plus fréquentes et plus graves quand la conception a lieu chez des patientes atteintes de néphropathie lupique ou d’anticorps antiphospholipidiques ou durant une période active de la maladie. Des poussées de lupus se produisent dans la majorité des grosseses et elles touchent souvent les systèmes rénal et hématologique. Elles tendent à être légères ou modérées et sont susceptibles aux traitements médicaux, surtout aux glucocorticoïdes. Le syndrome du lupus néonatal est une complication rare du LED maternal. II est lié au passage transplacentaire des anticorps anti-Ro ou anti-La, ce qui entraîne des manifestations cutanées, hématologiques et cardiaques. Le cœur se trouve fréquemment affecté dans ce syndrome alors qu’un blocage cardiaque congénital complet se manifeste à cause de la destruction du système de conduction fœtale par les anticorps. Des stéroïdes administrés avant l’accouchement peuvent s’avérer utiles pour le traitement et la prévention d’un blocage cardiaque congénital. Des soins prénatals optimaux et une surveillance fœtale avant l’accouchement peuvent permettre à des patientes atteintes de LED d’avoir une grossesse réussie malgré le risque élevé qu’elle comporte." @default.
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• W2401786787 date "2000-12-01" @default.
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• W2401786787 title "Systemic Lupus Erythematosus in Pregnancy" @default.
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• W2401786787 doi "https://doi.org/10.1016/s0849-5831(16)31134-x" @default.
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